Ignacio Vazquez-Garcia
Assistant Professor @ Massachusetts General Hospital | Harvard Medical School | Broad Institute
vazquezgarcialab.mgh.harvard.edu
- Reposted by Ignacio Vazquez-GarciaStudying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
- Reposted by Ignacio Vazquez-GarciaGoldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team
- Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process? In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion. www.nature.com/articles/s41...
- Reposted by Ignacio Vazquez-Garcia[Not loaded yet]
- Reposted by Ignacio Vazquez-GarciaThe stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper: www.nature.com/articles/s41...
