Manideep Chavali
Assistant Professor @ OHSU 🧠 | Neuroscientist: OPCs, vessels & brain mysteries. #newPI
- Reposted by Manideep ChavaliMyelin is repaired by constitutive differentiation of oligodendrocyte progenitors www.science.org/doi/10.1126/...
- Reposted by Manideep ChavaliWe identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
- Reposted by Manideep ChavaliRodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. rupress.org/jcb/article/... 📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025 #Mitochondria
- Reposted by Manideep ChavaliOrganelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
- Organelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by Manideep ChavaliOrganelles harbour pH gradients biorxiv.org/content/10.64898/20…
- Reposted by Manideep ChavaliOur work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
- PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
- Reposted by Manideep ChavaliCheck out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish." lnkd.in/gN7z6th4
- Reposted by Manideep ChavaliObituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Manideep ChavaliOur postdoc ad is up on the SDB website! Come to Portland and study regenerative neurogenesis in planarians and zebrafish: www.sdbonline.org/resource?Res...
- Reposted by Manideep ChavaliNature research paper: Axonal injury is a targetable driver of glioblastoma progression go.nature.com/4lFmpiN
- Reposted by Manideep ChavaliAnother beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
- Reposted by Manideep ChavaliFantastic new study on the role of TMEM63a in oligodendrocyte-dependent myelination in the CNS from the Swetha Murthy lab: pubmed.ncbi.nlm.nih.gov/40694323/
- Reposted by Manideep Chavali
- Reposted by Manideep ChavaliDirectional growth of developing myelin mediated by Wnt gradient and required for proper axon functions biorxiv.org/content/10.1101/202…
- Reposted by Manideep ChavaliFor those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...
- Reposted by Manideep ChavaliNew paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 www.nature.com/articles/s41...
- Reposted by Manideep ChavaliGenetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity biorxiv.org/content/10.1101/202…
