A great pleasure to share our newest paper out this morning
@cp-molcell.bsky.social. We show that damage to nascent RNAs should not be ignored, and under certain conditions, these can turn into DNA breaks. We call this phenomena RDIBs (RNA Damage Induced Breaks).
www.cell.com/molecular-ce...
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks
Tsao et al. uncover a novel pathway for genotoxicity, termed RNA-damage-induced DNA
breaks (RDIBs). The mechanism for preventing RDIBs is orchestrated by YTHDC1 along
with the THO complex, which funct...
