John Novembre
Population geneticist, University of Chicago
- Reposted by John NovembreThe 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.
- Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change
- This was a large collaborative piece of work with the lead efforts by student @maggiesteiner.bsky.social and former postdoc Dan Rice. It's well-timed for Maggie especially as she is defending her thesis on Monday!
- Reposted by John NovembreNew work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
- Check it out - PhD student @maggiesteiner.bsky.social's nice thread and link to our new preprint on how sample design, in terms of how geographically narrow vs broad a sample is, impacts the discovery/SFS of deleterious variants.
- Excited to share a new preprint with @jnovembre.bsky.social ! We use a combination of population genetic theory, simulation, and data analysis to ask: how does study design in genetic studies (including biobanks) impact the discovery of rare, deleterious variants?
- One reason I love what come out of this project is that Dan Rice and @maggiesteiner.bsky.social got in the trenches and developed theory for a model with mutation, selection, drift, geographic dispersal, -and- uneven geographic sampling, which is remarkable simply from a modeling perspective.
- #ASHG24 - Check out our new methods to reveal population structure through time -- poster 3026F presented today by Ahmed Selim from the lab!
- #ASHG24 make your way to today’s Novembre lab posters 3015 (label free reference matching, @LukeAnderTroc) 3016 (rare variant discovery, @maggiecsteiner ) and 4041 (impacts of multigeneration shared environments, @mkiravn) to see some great science!
- Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.
- Reposted by John NovembreAllele ages provide limited information about the strength of negative selection https://www.biorxiv.org/content/10.1101/2024.08.06.606888v1
