Osteoporosis NL
For public & professionals scientific news about osteoporosis and bone disease by Coen Netelenbos, em. prof. endocrinology Amsterdam UMC, NL. All views are mine.
- The Osteoporotic Fractures in Men Study (MrOS): a 25-year landmark study of skeletal health in older men. JA Cauley et al. JBMR 5 Feb 2026 shorturl.at/IYaGL …fine overview and summary of results
- Bone complications in Cushing`s syndrome in European registry study of 1682 patients of which 766(45%) had DXA examination at baseline, of whom 157 OP at spine and 103 at hip. A Z-Wełna et al. Ann Endocrinol 2026 Feb 3. shorturl.at/7ZGxJ …disappointing neglect of care for bone health?
- Clear mismatch between high fracture burden and low clinical engagement in bone health assessment in 79 patients with endogenous Cushing's Syndr. treaed in Imperial College NHS Trust, London. P Behary et al. Clin Endocrinol 2025 Dec 21 shorturl.at/rLzmj …no clinical guidelines present!
- U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office | Science | AAAS www.science.org/content/arti...
- The role of newly identified circular RNAs in mediating the protective effects of exercise against muscle degeneration and aging. Bo Li et al. Biogerontology 30 Jan 2026 shorturl.at/JYsNy ...very interesting but many knowledge gaps
- Diverse exercise modalities in alleviating osteoporosis: a narrative review. W Zou & R Liu Endocrine 3 Feb 2026 shorturl.at/f9oBf …illustrative fine educational review
- Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity. Alan Fappi et al. J Cachexia Sarcopenia Muscle 2026 Feb shorturl.at/Iedm5 … is associated with greater fatigability during repeated contractions with important clinical implications
- Correcting for extrinsic mortality raises estimate for heritability of human life span in twin and sibling studies to~55%, more than twice previous estimates. Ben Shenhar et al. Science 29 Jan 2026 shorturl.at/I1Zgl …important message and in line with heritability of most human traits
- Less education, lower income, and health care card ownership are associated with ↓bone, muscle, and physical function in cross-sectional study of 300 older Australian adults. J Talevski et al. Arch Osteoporos 1 Feb 2026 shorturl.at/FD66d …greater risk of developing osteoporosis and sarcopenia
- Longitudinal associations of dietary intake, physical activity, and short-chain fatty acids with bone development in early postmenopausal women. MV Geraldi et al. Osteoporos Int 2 Feb 2026 shorturl.at/DtOiE … role of specific dietary components and gut microbiota-derived metabolites
- In Individuals with Osteogenesis Imperfecta, Cephalometric Findings Suggest that Bisphosphonate Therapy May Improve Craniofacial Growth. H Tuurala et al. Calcified Tiss Int 31 Jan 2026 shorturl.at/le2Ed …fine retrospective study in 36 persons
- Bridging skeletal stem cell diversity and human skeletal modelling .Shoichiro Tani. JBMM 28 Jan 2026 shorturl.at/xBfME ...educational and important update
- 3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial. BZ Leder et al. Lancet 29 Jan 2026 shorturl.at/CQxoE ...could broaden access to this effective therapy
- Dietary Habits and Osteoporotic Fracture Risk: Retrospective Cohort Study Using Large-Scale Japanese Claims Data. H Nakajima et al. J Endocr Soc 2025 Aug 28 shorturl.at/cdnhY …skipping breakfast and having a late dinner are independently associated with a higher risk of osteoporotic fracture
- High prevalence of osteopenia and osteoporosis amongst patients undergoing total knee and total hip arthroplasty (66.86%); bisphosphonates may decrease risk of revisions. RMY Wong et al. J Clin Med 2025 Dec 11 shorturl.at/CuvGC … syst review & meta-analysis …no info about possible effect anabolics
- Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment. Teun J de Vries et al. Scand J Immunol 24 Jan 2026 shorturl.at/Yt4XF …unexpected interesting finding
- thanks to so many cowardly Americans it becomes possible for the orange usurper to destroy the stable world order
- The Multifaceted Role of p53 in Musculoskeletal Diseases: A Comprehensive Review. M Hossain et al. Int J Rheum Dis 26 Dec 2025 shorturl.at/f4dP4 …further clinical validation is essential
- Colchicine suppresses adipogenic differentiation while favouring osteoblast commitment of mesenchymal stem cells: implications for bone adiposity control. M López-Fagúndez et al. Pharmaceutics 16 Jan 2026 shorturl.at/86kk0 …involving microtubule homeostasis alteration
- Fracture probability with FRAX is predictive of fall-associated hospitalization in 88,684 persons of the Manitoba BMD Registry. F Zarzour et al. JBMR 28 Jan 2026 shorturl.at/im8RY …may help to identify individuals also at high risk for falls and apply measures to decrease this risk
- Omega-3 fatty acids vs placebo did not reduce incident fracture risk over 5.3 years in 25,871 elderly and had no effect on spine or hip BMD nor on bone strength over 2 years in 771 persons. MS LeBoff et al JBMR 28 Jan 2026 shorturl.at/VpdKN …ancillary study to VITAL study
- Site-specific inverse associations between FGF23 levels and marrow adiposity content at the proximal femur in 199 PMP women with normal phosphate. Paccou J et al. Bone 29 Jan 2026 shorturl.at/kzxu2 ...Proton Density Fat Fraction (PDFF) using MRI …cross-sectional study
- Sex-specific biomarkers predict bone mineral density loss at the contralateral hip after hip fracture. AM Rathbun et al. Bone 29 Jan 2026 shorturl.at/eZl23 …interesting longitudinal study
- Calcium, FSH, and the changing bones of menopause: a longitudinal look at the silent transformation of 5 years in 56 patients. JL Puranda et al. Bone 26 Jan 2026 shorturl.at/nlfZs ...elevated FSH may independently contribute to bone loss
- The surprisingly big health benefits of just a little exercise. Mariana Lenharo. Nature news feature 28 Jan 2026 shorturl.at/Nwh0t …the more, the better — up to a point …exercise snacks’ and other forms of everyday movement can greatly reduce the risk of heart disease and death
- Physical activity types, variety, and mortality: 2 prospective cohort studies. Han Han et al. BMJ Med 2026 Jan 20 shorturl.at/bRitM ...most types of physical activity associated with lower mortality ….active lifestyle and engagement in multiple physical activities may facilitate long term survival
- WE DO CARE INDEED! www.nejm.org/doi/pdf/10.1... bernard e trappey md
- Fracture risks in patients with arginine vasopressin deficiency: nationwide matched cohort study Korea. SS Park et al. Osteoporos Int 28 Jan 2026 shorturl.at/6Ghj8 …hip fracture risk↑ (HR 1.83; 95% CI, 1.06–3.17) in female patients but was not observed in male patients
- Opportunistic osteoporosis assessment from routine CT; use of contrast agents in CT scans significantly influences BMD measurements, which can lead to misdiagnosis. J Gotta et al. Eur Radiol 2025 shorturl.at/9eiUR …see also A Abudayeh et al. Eur Radiol 27 Jan 2026 shorturl.at/Vf7h7
- A Consensus Statement on the management of Vertebral Fractures in CKD stages G4-G5D. Maria Fusaro et al. Nephrol Dial Transplant 2025 Nov 28 shorturl.at/g9CfE …global consensus and recommendations
- Incidence of first and subsequent fractures in multiple myeloma patients: a parallel cohort study using UK CPRD dataset. R Vijjhalwar et al. Osteoporos Int 26 Jan 2026 shorturl.at/4cMPb … highlight the potential for earlier MM diagnosis in adults presenting with a major fracture
- Osteoarthritic knee: Advances in Epidemiology, Emerging Etiopathologies and Adipose-Derived Stem Cells-based Therapies. Chian-Her Lee et al. Aging Dis 20 Jan 2026 shorturl.at/UqybL …comprehensive update
- Six months of teriparatide in women with anorexia nervosa may induce positive changes at the intertrochanteric region but no changes of microarchitecture at the radius and tibia in placebo controlled RCT. T Amorim et al. Osteoporos Int 27 Jan 2026 shorturl.at/cpzQl … longer studies necessary
- Genomic and Epigenomic Landscapes of Sarcopenia: From Molecular Etiology to Precision Interventions. Ji-Yong Sung & Jung Woo Lee. Aging Dis 2026 Jan 5 shorturl.at/cwaA9 …fine illustrative update
- Exercise, Exerkines, and Sarcopenia. HS Chung & KM Choi. Diabetes Metab J 1 Jan 2026 shorturl.at/Hq9Au ...recently identified exerkines relevant to skeletal muscle physiology and their implications in the pathophysiology of sarcopenia
- Chinese expert consensus on dietary nutrition prescriptions and exercise intervention for sarcopenia (2025). Jianqin Sun et al. Asia Pac J Clin Nutr 2026;35(1):1-11 doi: 10.6133/apjcn.202602_35(1).0001 …based on EBM evidence in the past ten years
- Reposted by Osteoporosis NL[Not loaded yet]
- Comprehensive Review of Therapeutic Efficacy and Underlying Mechanisms of Various Exercise Modalities in Treating Osteoporosis. Y Xie et al. Aging Dis 2025 18 Dec. shorturl.at/I1cUH … deeper mechanistic insights into exercise-mediated bone protection and offers evidence-based perspectives
- Seeing beyond the surface: bone histomorphometry re-visited-implications for diagnostic pathology. T Diamond et al. Pathology RCPA 2025 Dec 5 shorturl.at/uhxMf ... justified plea for technology that is unfortunately used less and less
- T-Cell Mediated Inflammation in Postmenopausal Osteoporosis. Di Wu et al. Front Immunol 2021 Jun 30 shorturl.at/Vaadc …fine update on the interactions between T cells and the skeletal system in the context of postmenopausal osteoporosis and studies on interventions
- Reposted by Osteoporosis NLRest in Peace Alex Jeffrey Pretti🙏🏾 The VA ICU Nurses send him off right 💔
- Challenges and pitfalls in diagnosing and managing severe gestational hypercalcemia. C Dewdney et al. JBMR 18 Jan 2026 shorturl.at/WFZaS … case report of CYP24A1 deficiency in pregnancy discussing diagnostic and treatment challenges
- Decreased Nonvertebral Fracture Incidence with Zoledronate Use For >3 Years: Post Hoc Analysis of an RCT. IR Reid et al. JBMR 22 Jan 2026 shorturl.at/5YdUC … longer term treatment may yield greater benefit to patients
- Dietary potassium restriction causes hypercalciuria, hypocalcemia and bone loss in male mice. SK Murali et al. JCI Insight 2026 Jan 22 shorturl.at/dZkP5 … impact bone health when K+ intake can be low or gastrointestinal loss high (eg anorexia nervosa, inflammatory bowel disease)
- GLP-2 alleviates postmenopausal osteoporosis by acting on osteoblasts through the PI3K/AKT/FOXO1 signalling pathway to downregulate FGF23 expression in mouse model. Kefen Wu et al. J Orthop Surg Res 2026 Jan 22 shorturl.at/lRNZt
- The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions. Yan Luo et al. Bone Res 19 Jan 2026 shorturl.at/efQcw …fine update
- The roles of the nerve-immune axis in modulating bone regeneration. Yubin Zhao et al. Bone Res 5 Jan 2026 shorturl.at/bKPgh … deepens the understanding of the nerve-immune axis in bone regeneration
- Molecular mechanisms and therapeutic implications of the sympathetic nervous system in bone-related disorders: a brain-bone axis perspective. Mingdong Liu et al. Bone Res 2025 Dec 2 shorturl.at/efQcw … advances understanding of neuroskeletal interactions
- Leptin Regulates Intervertebral Disc Calcification and Ossification by Promoting Glycolysis Through OCN/HIF-1α Axis. Haoxi Li et al. J Cell Mol Med 2026 Jan shorturl.at/fYloj … first study showing the effects of leptin on the intervertebral disc and cartilage endplate cells in rat model
- Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. Y Kang et al. 2026 Jan 7 shorturl.at/NgZJW …findings offer insights and potential translational path for slowing down
