Adam Marblestone
Technologist, scientist. Co-founder of Convergent Research.
- Reposted by Adam MarblestoneA special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI. Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders. 1/2
- Reposted by Adam MarblestoneSo you sequenced a billion+ bases. That don’t impress me much. JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
- Check out our latest work! JERBOA, a toolkit for making genome-wide genetics work in non-model bacteria. blog.cultivarium.org/p/so-youve-s...
- Reposted by Adam MarblestoneLight-microscopy brain mapping was picked as one of 7 technologies to watch in 2026 by Nature! Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
- Reposted by Adam MarblestoneSynaptic MEMOIR: mapping individual synapses of neurons with protein barcodes biorxiv.org/content/10.1101/202…
- Reposted by Adam MarblestoneIt's been an incredibly exciting year in metascience at large, and for us at Convergent. Last week, the NSF announced their Tech Labs Initiative. www.essentialtechnology.blog/p/the-future...
- Reposted by Adam MarblestoneDim Red Dot Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time. It lies beyond the Affectable Universe. Let me explain… 1/🧵
- Reposted by Adam MarblestoneLast Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
- Reposted by Adam MarblestoneA Vision of Metascience; How does the culture of science change and improve? We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science pllqt.it/Qg2rOs
- Reposted by Adam MarblestoneTo mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play: fas.org/publication/...
- If you've been interested in FROs, you'll want to see this from NSF: sam.gov/opp/7332ade9... "sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
- Reposted by Adam MarblestoneA genetic platform for a biocementation bacterium biorxiv.org/content/10.64898/20…
- Reposted by Adam Marblestone[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal. We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets. Full announcement: www.cworthy.org/media/cworth...
- Reposted by Adam MarblestoneA global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
- Reposted by Adam MarblestoneHave a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization www.biorxiv.org/content/10.1...
- Reposted by Adam MarblestoneAnnounced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co. Learn more: evebio.org/pharmome-dat...
- Reposted by Adam MarblestonePoster now til 12 pm, come check it out at V6! #SfN25
- Reposted by Adam MarblestoneIs there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
- Reposted by Adam MarblestoneAs AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓ link.aria.org.uk/ST-thesis-BS
- Reposted by Adam MarblestoneIt is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
- Same for neuroscience. The lack of ability to measure many neurons’ activity, perturb them, and measure intracellular processes and connections is what limits understanding the brain. The key barriers are not algorithms or AI. 🧪#neuroscience 🧠🤖 #MLSky
- Reposted by Adam Marblestonecool! tools to making it easier to work with 𝘐𝘥𝘦𝘰𝘯𝘦𝘭𝘭𝘢 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴 (now 𝘗𝘪𝘴𝘤𝘪𝘯𝘪𝘣𝘢𝘤𝘵𝘦𝘳 𝘴𝘢𝘬𝘢𝘪𝘦𝘯𝘴𝘪𝘴) for PET degradation #MicroSky
- Functional genomics in a microbe that degrades and metabolizes PET plastic biorxiv.org/content/10.1101/202…
- Reposted by Adam MarblestoneCool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next? Check out the toolkit here: www.addgene.org/kits/cultiva...
- Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
- Reposted by Adam MarblestoneVery happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
- Functional genomics in a microbe that degrades and metabolizes PET plastic biorxiv.org/content/10.1101/202…
- Reposted by Adam MarblestoneI am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1... We analyses over 8500 neurons in a songbird basal ganglia dataset. To explore this and two other stories more interactively, also check out our website! www.songbird-connectomics.org
- Reposted by Adam MarblestoneOur new preprint outlining how to make 1000-plex mass tags!
- A bit dense, but the important message is dead simple: We got to cite the E = mc² paper! Kidding :) The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed. Here's how: www.biorxiv.org/content/10.1... #TeamMassSpec #Proteomics 🧪
- Reposted by Adam MarblestoneA bit dense, but the important message is dead simple: We got to cite the E = mc² paper! Kidding :) The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed. Here's how: www.biorxiv.org/content/10.1... #TeamMassSpec #Proteomics 🧪
- Reposted by Adam MarblestoneWe’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below: docs.google.com/document/d/1...
- Reposted by Adam MarblestoneThanks for contributing your expertise!!
- I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy. prism.cultivarium.org/protocols/20...
- Reposted by Adam MarblestoneI got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy. prism.cultivarium.org/protocols/20...
- Reposted by Adam MarblestoneWhat is the future missing? convergentresearch.org
- Reposted by Adam Marblestone8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨
- Reposted by Adam MarblestoneExcited to try this! The waiting list makes me even more curious
- Reposted by Adam MarblestoneExcited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
- Reposted by Adam Marblestone💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others. Try it out! live.lean-lang.org
- Reposted by Adam MarblestoneWait uh, what?? 🤩
- Reposted by Adam MarblestoneThe development of new, transformative material processes has stagnated. In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓ link.aria.org.uk/UF-thesis-BS
- Reposted by Adam MarblestoneAn Introduction to Mars Terraforming, 2025 Workshop Summary arxiv.org/abs/2510.07344
- I have never seen a better conference name
- ItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/
- Reposted by Adam MarblestoneItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/
- Reposted by Adam MarblestonePlease spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood. If you are curious to learn more, this short talk provides a good overview of why, what and how. www.youtube.com/watch?v=gjIK...
- Reposted by Adam MarblestoneI don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:
- Reposted by Adam MarblestoneSay what? 👍
- We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
- Reposted by Adam MarblestoneSoooooo when is bluesky deploying bridging systems arxiv.org/abs/2301.09976
- Reposted by Adam MarblestoneI love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
- Reposted by Adam MarblestoneLead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Adam MarblestoneExciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
- Reposted by Adam MarblestonePrecision Neuroscience published their high-density ECoG in Nature Biomed. Eng. The startup shows a 1,024-channel grid implanted through a cortical slit in pigs, and intraoperative neural recordings and stimulation in five humans at sub-mm resolution. #neuroskyence @precisionneuro.bsky.social
- Reposted by Adam MarblestoneEarlier this year, @parallelsq.bsky.social hosted a research fest. We began with a broad perspective: ◾️ A century of remarkable progress! Proteomics drove conceptual discoveries and medical treatments. Listen to what's next! Proteomics: The arc of progress youtu.be/Sc2QLXb84XI?...
- Reposted by Adam Marblestone[This post could not be retrieved]
- Reposted by Adam MarblestoneAnnouncing ALLFED's new study in Earth System Dynamics: Even modest crop declines from nuclear war or infrastructure collapse could trigger cascading food trade disruptions. Global food systems are more fragile than we think. allfed.info/research/pub...
- Reposted by Adam MarblestoneWonderful to collaborate with, and to support as an advisor, E11 Bio - and to announce PRISM, a technology for mapping brains in a self-correcting way, by barcoding neurons followed by expansion microscopy! Thread below by E11 Bio CEO Andrew Payne, with preprint at, www.biorxiv.org/content/10.1...
- E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
- Reposted by Adam MarblestoneLong story short: PRISM has the potential to solve the connectomics reconstruction bottleneck for good. Fantastic collaboration with E11, MIT, and the Crick!
- E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
- Reposted by Adam Marblestonehello, we are working on brain mapping and now you can read about it! it has beautiful neurons (shout out to cell 1492), cool multiplexing tricks, and cell barcodes. there are live data links, my first addgene collection and much much more
- E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
