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Hubert Salvail

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Assistant Professor at University of Central Florida. Stressing bacteria, pesting pathogens and folding RNA. Foodie, music lover and traveller. Fier Québécois.

Joined November 2024

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Hubert Salvail handle.invalid · Dec 9, 2025
Check out our new article! Congrats to Michelle Prophete, Alex Mabel and Payton Bowman for their great work! Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH | mSphere journals.asm.org/doi/10.1128/...
Small RNA promotes negative feedback of the master virulence regulator PhoP by repressing the PhoQ sensor enhancer UgtL in acidic pH | mSphere

To cause disease, pathogens must express their virulence genes at the right time and in proper levels. Here, we establish that a small RNA (sRNA) restricts the activation of a regulator critical for t...

journals.asm.org

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Hubert Salvail handle.invalid · May 22, 2025
Check out our new review on guanidine biology! Stay tuned for more exciting findings on guanidine from our group. From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology | Journal of Bacteriology journals.asm.org/doi/10.1128/...
From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology | Journal of Bacteriology

More than two decades ago, the first naturally occurring mRNA elements regulating gene expression by directly binding target ligands, termed riboswitches, were discovered in bacteria (1–4). Since then, more than 55 classes of riboswitches have been characterized (5, 6), advancing our general knowledge of gene regulation and stress response, but also unveiling unexpected biological roles for compounds whose relevance had remained elusive. A notable example is the discovery of riboswitches recognizing c-di-AMP and c-AMP-GMP (7, 8), which hinted at important biological functions for the two molecules that were later revealed to act as second messengers in key cellular processes such as biofilm formation, chemotaxis, sporulation, and virulence (9–11).

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Nick Pokorzynski handle.invalid · Mar 25, 2025
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Nick Pokorzynski handle.invalid · Jan 6, 2025
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Stephen Floor snf.bsky.social · Nov 27, 2024
sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cel…

sciencedirect.com

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Ran Blekhman blekhman.bsky.social · Nov 19, 2024
Enjoying this deep dive into the link between coffee and the microbiome They found a microbe (Lawsonibacter asaccharolyticus) that is 4- to 8-fold more abundant in coffee drinkers, and correlates with coffee intake in worldwide populations www.nature.com/articles/s41...
Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology

Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

nature.com

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Andreas Bäumler abaumler.bsky.social · Nov 19, 2024
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