Hiro Ebina / 蛯名裕久
A wandering and wondering molecular biologist and geneticist, currently at Switzerland🇨🇭| Posdoc in Barral lab, ETH Zürich @barrallabeth.bsky.social | pombe | Interested in the stability and plasticity of the genome, genetic immunity in eukaryotes
- Reposted by Hiro Ebina / 蛯名裕久This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1.... This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.
- Reposted by Hiro Ebina / 蛯名裕久[Not loaded yet]
- Reposted by Hiro Ebina / 蛯名裕久Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction! Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1 doi.org/10.1101/2025...
- Reposted by Hiro Ebina / 蛯名裕久New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity www.biorxiv.org/content/10.1...
- Reposted by Hiro Ebina / 蛯名裕久[Not loaded yet]
- Reposted by Hiro Ebina / 蛯名裕久How many chromosomes can an animal have? In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact. www.cell.com/current-biol...
- Reposted by Hiro Ebina / 蛯名裕久1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...
- Reposted by Hiro Ebina / 蛯名裕久Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...
- Reposted by Hiro Ebina / 蛯名裕久🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in @natmicrobiol.nature.com uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s415... ⬇️
- Reposted by Hiro Ebina / 蛯名裕久Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains: www.epfl.ch/about/workin...
- Hello everyone, I will give a talk at SSM 2025 in Interlaken, Switzerland (August 27th, Day 1, Session 8) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room! #SSM2025 www.meeting-com.ch/en/conferenc...
- www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
- www.biorxiv.org/content/10.1... NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin | bioRxiv
- Reposted by Hiro Ebina / 蛯名裕久We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity! www.nature.com/naturecareer...
- Reposted by Hiro Ebina / 蛯名裕久We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/
- www.nature.com/articles/s41... HP1 loses its chromatin clustering and phase separation function across evolution | Nature Communications
- Hello everyone, I will give a talk at ICYGM32/Yeast 2025 in Paris (July 24th, Day 4, Workshop 18) with the title "Discrimination of exogenous DNA by mitotic heterochromatin in fission yeast." I'm looking forward to seeing many people in the room! #ICYGM32 #yeast2025 #vivapombe
- Exploring the relationship of transposable elements and ageing: causes and consequences url:https://academic.oup.com/gbe/article/doi/10.1093/gbe/evaf088/8133184
- Cryptic infection of a giant virus in a unicellular green alga | Science www.science.org/doi/10.1126/...
- Most bacterial gene families are biased toward specific chromosomal positions | Science www.science.org/doi/10.1126/...
- Microtubules in Asgard archaea: Cell www.cell.com/cell/fulltex...
- Reposted by Hiro Ebina / 蛯名裕久[Not loaded yet]
- Evolving concepts of the protein universe: iScience www.cell.com/iscience/ful...
- Genome size variation in Schizosacchaomycota is extremely small www.biorxiv.org/content/10.1...
- Reposted by Hiro Ebina / 蛯名裕久
Since April, we have been busy curating pathways using GO-CAM pathway modelling. So far, 466 proteins (33 pathways) have been modelled. We have modelled signalling pathways, metabolic pathways, and other processes. The full list is here: www.pombase.org/documentatio..., and will increase weekly!
