Adrià Sogues
Spores, Bacterial S-layers, Cell Envelope & Cell Division. Structural Microbiologist 💎❄️🔬 at Institut Pasteur (Paris). Formerly at VIB-VUB in Brussels (EMBO & MSCA fellow) 🇫🇷🇧🇪🇪🇸
- Reposted by Adrià SoguesSAVE THE DATE! The next instalment of the long-running Bacterial and Archaeal Cell Division Conference will take place at www.marriott.com/en-us/hotels..., Italy from the 20th to 23rd of April 2027. Organisers: me, @s-lab.bsky.social, @awehenkel.bsky.social. More info soon. #MicroSky
- Preprint out! That was a really enjoyable collaboration! We report the structure and higher-order assembly of AbpX, a biofilm component in Archaea. And as a bonus, this protein gave me one of the most beautiful crystals I’ve ever had! 🤩💎
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- Reposted by Adrià SoguesApply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky
- S-layer, a (re)blooming field and a fascinating world for both microbiologists and structural biologists. A very complete and up-to-date review of S-layer functions, structure, and biogenesis. Congrats to all the authors!
- Assembly, architecture and functional roles of microbial surface layers Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social. S-layers are everywhere! www.nature.com/articles/s41...
- Reposted by Adrià Sogues🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training 📜 www.biorxiv.org/content/10.1...
- The line-up I would dream of 🤩
- We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures. Join our speakers & register today! ➡️https://bit.ly/47rtkbw #ProkaryoticCellBio
- Reposted by Adrià SoguesCryo-Flow : when science freezes and flows ❄️ After turning her thesis on tuberculosis into a rap, Yaëlle Wormser aka Lady Pipette, doctoral student at the Institut Pasteur, is back with a new track — Cryo-Flow — a song that turns Cryo-Electron Microscopy (Cryo-EM) into rhythm & rhyme. @pasteur.fr
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- A new chapter begins! Happy to be back at the @pasteur.fr , a place that feels like home. Excited for the journey ahead and all the science to come!
- Reposted by Adrià Sogues🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...
- Many spores from the Firmicutes group are decorated with hair-like structures. Since the 60s, they remained a mystery. @remaut-lab.bsky.social named these fibres ENdospore Appendages (ENAs). Using Cryo-ID, we report the identity, structure and function of F-ENA. www.nature.com/articles/s41...
- Reposted by Adrià SoguesThrilled to see our work published in @embojournal.org #asgard #archaea #cytoskeleton #tubulin #FtsZ We sincerely appreciate the constructive peer review and the reviewers’ thoughtful, supportive feedback, which greatly strengthened our work.
- Insights into the origins of the #tubulin / #FtsZ superfamily: @syncellbiolab.bsky.social, Pananghat Gayathri et al show that two #Asgard archaeal paralogs OdinFtsZ1 and OdinFtsZ2 form distinct filamental structures, and employ different modes of membrane tethering www.embopress.org/doi/full/10....
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- Happy to see the final version out! Cryo-EM structure of the PS2 S-layer in Corynebacterium 🔬! We show it provides mechanical support to the cell wall and assembles at the poles in coordination with PG. It can also be used for covalent surface display. www.pnas.org/doi/10.1073/... #microsky
- 1/4🧵 We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.
- 2/4🧵We show across different strains that the S-layer provides mechanical support to the cell wall, especially when it's compromised (such as after lysozyme treatment). The S-layer acts as a protective scaffold, reinforcing the envelope under stress.
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View full threadDon’t forget to check out the fantastic complementary work by @tbharat-lab.bsky.social and @bupbuse.bsky.social journals.plos.org/plosbiology/...
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- Reposted by Adrià Sogues#MicroSky Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social www.sciencedirect.com/science/arti...
- Reposted by Adrià SoguesNew review from our lab! Compartmentalization during bacterial spore formation. Focusing on latest discoveries in Bacillus subtilis #subtiwiki www.sciencedirect.com/science/arti...
- Reposted by Adrià SoguesFolddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco
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- Reposted by Adrià SoguesRunning Phenix and stuck? Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program. Big thanks to Tom Willinger for making this happen! Try it out: phenix-online.org/version_docs...
- Reposted by Adrià Sogues🎶 Science meets creativity with TuberKiller! Yaëlle Wormser, PhD student featured in the My PhD at the Institut Pasteur series, raps her tuberculosis research. Discover how music and science collide to make research unforgettable! 👏 🎧 TuberKiller is also available on Spotify! @pasteur.fr
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- Reposted by Adrià SoguesHow does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species". Happy to see this paper in print @natcomms.nature.com. Nice work by @mariedelaby.bsky.social, Liu Yang et al. See original 🧵, different colours, same data and conclusions.
- Reposted by Adrià SoguesThe nucleoid of rapidly growing E. coli 🦠 localizes close to the inner membrane & is organized by transcription, translation, & cell geometry @michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social #microbiology
- Reposted by Adrià SoguesThe archaeal S-layer is not only pretty, it also carries crucial cellular functions, and the list keeps growing! @sshamphavi.bsky.social @marleenvw.bsky.social @archaellum.bsky.social and I wrote a little sheath sheet (+10 pts if you got the pun) 📖 Curr Opin Cell Biol 🔗 doi.org/10.1016/j.ce...
- I’m thrilled to finally share this preprint! It contains a WOW Cryo-EM structure (likely one of the strongest protein fibers known to man 🤯), but we’ve also untangled its biological function: a novel type of virulence factor💀! www.researchsquare.com/article/rs-6...
- In our latest preprint we used cryoEM to solve the structure of A-ENA fibers and show that they are stabilized by 10 isopeptide bonds per monomer. A-ENA couples the spore to the cry-toxins, and in doing so increases the virulence of Bacillus thuringiensis: www.researchsquare.com/article/rs-6...
- Reposted by Adrià Sogues📖 New publication from the TacC team at MMSB! Congratulations to Nathan Fraikin et al.! @nfrk92.bsky.social @agathe-couturier.bsky.social
- Reposted by Adrià SoguesOur review on Z-ring placement mechanisms in cocci is out! This was a fun one to write! #Microsky 🦠🧫
- New preprint from the @remaut-lab.bsky.social ! Happy to share our latest work on a new member of the ENA family, protein fibers found on the spore’s surface. Using CryoID @mikesleutel.bsky.social identified F-ENA in BTK. The paper dives deep into its structure analysis by integrating X-ray and AF3
- Link to the preprint here: www.biorxiv.org/content/10.1...
- Reposted by Adrià SoguesUsing Bacillus subtilis as a model organism, this #JBacteriology review describes the signal transduction pathway & events leading to spore germination, incorporating the latest findings on transcription and translation likely detected during germination. asm.social/2g2
- Our second paper of the week is also out!🥳 Dive into the interface of S-layers and nanobodies in our companion paper! In collaboration with Alex Pak (Colorado, USA), we explore how nanobodies destabilize S-layers using machine learning and molecular dynamics.
- Finally out!🤩 if you were wondering how the Sap S-layer of B. anthracis looks, we have the answer! We've used an integrative structural biology approach to solve the atomic details. I wanted to make a thread highlighting the main results, but @mishakudryashev.bsky.social already did a nice job👇
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- Reposted by Adrià SoguesBacterial cell surface starter pack ! Trying to make it easier to find people with the same love for bacterial membranes and whatever goes in and through them. Leave a comment if you want to be added go.bsky.app/KfHSqvtat://did:plc:apv6euvpiuafoogmjzpwxbkt/app.bsky.graph.starterpack/3lb3ihst4pt2k
