The Elowitz Lab at Caltech
Synthetic biology and systems biology. https://www.elowitz.caltech.edu
- This was an energizing event with excellent scientists in a gorgeous location. Thank you for making it happen!
- Congratulations @elowitzlab.bsky.social on the @iubmb.bsky.social Jubilee Award🌟 ! 🎉🎉🎉 @caltech.edu | @rmichaelalvarez.bsky.social, @caltechlcssp.bsky.social Co-Director
- Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. www.biorxiv.org/content/10.1...
- In this paradigm, engineered proteins are introduced into cancer and healthy cells using LNP-delivered mRNA. They then sense cancer markers (such as mutant Ras) and trigger engineered cell death effectors (caspases or gasdermins) only in cancer cells. (idealized schematic)
- Why therapeutic circuits? Sense-and-kill ≠ inhibit. Oncogene inhibition indirectly induces cell death, but is susceptible to resistance through compensatory signaling. Circuits directly rewire oncogenes to cell death --> less chance of resistance. Other benefits as well.
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View full threadThis work was led by brilliant students Andrew Lu, Lukas Moeller, and Stephen Moore, and is a collaboration with Hao Zhu and Dan Siegwart at UTSW. If you have experience in animal cancer models and are interested in circuit therapeutics, please reach out.
- Congratulations to Dhiraj and the other amazing fellows
- Reposted by The Elowitz Lab at CaltechMy first project in the @elowitzlab.bsky.social is finally out in @cellpress.bsky.social! We explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓ doi.org/10.1016/j.ce...
- Reposted by The Elowitz Lab at CaltechNew study in @cellpress.bsky.social by Allen Distinguished Investigator @elowitzlab.bsky.social and collaborators explores the versatility of protein dimers. #FrontierScience 🔗 www.cell.com/cell/fulltex...
- Reposted by The Elowitz Lab at CaltechI really enjoyed reading this preprint, congrats @elowitzlab.bsky.social and team!
- New study in @cellpress.bsky.social by Allen Distinguished Investigator @elowitzlab.bsky.social and collaborators explores the versatility of protein dimers. #FrontierScience 🔗 www.cell.com/cell/fulltex...
- Reposted by The Elowitz Lab at CaltechAnother assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...
- Really enjoying Uri Alon’s characteristically wonderful lectures on aging: www.weizmann.ac.il/mcb/alon/cou...
- Reposted by The Elowitz Lab at CaltechCould one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
- "The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing. www.nature.com/articles/s41...
