Davit Potoyan
We are a curiosity-driven theoretical/computational biophysics lab at Iowa State University. Interested in biomolecular condensates, allostery, gene regulatory networks, chromatin, the origin of life, and RNA functions
- Our RNA condensate work is finally out! Using simulations, we uncover the origin of the lower critical solution temperature (LCST) behaviour underlying thermo, iono-sensing functions in pure RNA condensates. www.pnas.org/doi/10.1073/...
- A new paper shows how LCD sequence patterns encode condensate dynamics and material properties. 🔹 Periodic repeats → Elasticity-dominated 🔹 Disordered sequences → Viscosity-dominated 🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states. doi.org/10.1371/jour...
- In collaboration with @priya-r-banerjee.bsky.social we dive a little deeper into the microscopic interactions and sequence patterns that are shaping condensate activation energies pubs.acs.org/doi/10.1021/... For more context see also our prior work www.science.org/doi/10.1126/...
