Chris Nickson
Intensivist, ECMO specialist, Clinician Educator. Calm amid a #FOAMed storm: LITFL.com & INTENSIVEblog.com
- RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults – The Bottom Line #foamed #foamcc www.thebottomline.org.uk/summaries/ic...
- Etomidate • LITFL Critical Care Compendium #foamed #foamcc Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial litfl.com/etomidate/
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- Reposted by Chris NicksonCo-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder Livestream -> www.criticalcarereviews.com @jama.com
- Reposted by Chris NicksonIn a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB @criticalcarereviews.com
- Reposted by Chris NicksonChief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results. Livestream -> www.criticalcarereviews.com @jama.com
- Reposted by Chris NicksonCo-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder Livestream -> www.criticalcarereviews.com @jama.com
- Reposted by Chris Nickson#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com
- Reposted by Chris NicksonRSI trial now starting ➡️ Etomidate vs Ketamine for RSI ➡️ Jonathan Casey & Matthew Semler presenting ➡️ Chris Nickson editorialising ➡️ Join the livestream - criticalcarereviews.com #ccrdownunder
- Reposted by Chris NicksonCongratulations to the RSI trial team #CCRdownunder
- In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB @criticalcarereviews.com
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- Reposted by Chris NicksonEditorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3
- Reposted by Chris NicksonSecond at #ccrdownunder - #IREHABtrial Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com
- Precision Therapy for Sepsis: The End of the Beginning? | Critical Care Medicine | JAMA | JAMA Network #ccrdownunder 2025 jamanetwork.com/journals/jam...
- Reposted by Chris NicksonRCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95
- Reposted by Chris Nickson📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis. #CCRdownunder ja.ma/4pMi8wt
- Reposted by Chris NicksonImmunoSep uses a double-dummy design. What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder
- RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95
- IMMUNOSEP trial - JAMA jamanetwork.com/journals/jam... #ccrdownunder 2025
- Reposted by Chris NicksonLooking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!
- Reposted by Chris NicksonUp first at #ccrdownunder - #IMMUNOSEPtrial Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com
- Reposted by Chris NicksonStruggling to keep up with the critical care literature? ➡️ We search it daily & curate the best papers ➡️ Delivered to your inbox each weekend ➡️ Try our Newsletter - there's nothing else like it Sample - criticalcarereviews.com/newsletters/... Subscription - criticalcarereviews.com/newsletters/...
- Reposted by Chris NicksonThere are now just under 50 days to CCR Down Under 2025. The programme is out - 8 superb trial results coming up. Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world! criticalcarereviews.com/meetings/ccr...
- Reposted by Chris NicksonThe 5th trial to be announced for CCR Down Under 2025 is ACTiVE Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients Join us in Melbourne, either in-person or online criticalcarereviews.com/meetings/ccr...
- Reposted by Chris Nickson🚩The 3rd trial result for CCR Down Under 2025 is ARISE-AFRICA🚩 ➡️Standard low flow oxygen vs nasal high flow oxygen vs CPAP in hypoxaemic respiratory failure ➡️Presenter Arthur Kwizera ➡️Join us in Melbourne criticalcarereviews.com/meetings/ccr... @precordialthump.bsky.social
- CCR Down Under 2025 - december 9th & 10th 2025 Melbourne is the place to be! Registrations are open 😁: criticalcarereviews.com/meetings/ccr... See you there! @criticalcarereviews.com
- Looking forward to this!
- The first trial for CCR Down Under 2025 is RSI from the Pragmatic Critical Care Research Group ➡️Ketamine vs etomidate for emergency tracheal intubation ➡️n= 2364 Join us in Melbourne - Dec 9 & 10 criticalcarereviews.com/meetings/ccr... CCR Down Under is run with the Alfred ICU & Monash Uni
- Dobutamine litfl.com/dobutamine/ I don’t often use dobutamine, but when I do I make sure I know about its cool racemic pharmacology (and the major clinical trials) #foamed #foamcc
- Suspended animation litfl.com/suspended-an... Ok, not really a core crit care topic and not coming to an ICU near you anytime soon… #foamcc #foamed
- Airway assistant (ala airway ally) litfl.com/airway-assis... the forgotten role in airway management in ED, ICU, and the wards… but an important one! #foamed #foamcc
- Unrecognised esophageal intubation litfl.com/unrecognised... Largely derived from the superb PUMA guidelines by @chrimesy.com et al #foamed #foamcc
- Metaraminol litfl.com/metaraminol/ A very commonly used drug in UK/ ANZ crit care - but one there is surprisingly little known about… #foamed #foamcc
- Semaglutide litfl.com/semaglutide/ Not a core ICU drug but we need know about GLP1R agonists! #foamed #foamcc
- Continuous beta-lactam infusions litfl.com/continuous-b... Is this the way to “make antibiotics great again”? #foamed #foamcc
- Reposted by Chris Nickson“On Not Betraying Our Trainees, Especially Now” I won an Extraordinary Achievement Award from the Critical Care Assembly last month The @atscommunity.bsky.social premier journal @atsblueeditor.bsky.social TODAY published the remarks I made on that occasion www.atsjournals.org/doi/10.1164/...
- Reposted by Chris NicksonThe second trial result for #CCR25 in Titanic Belfast in June is GASTROSAM Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition Join us in June for the best critical care trials in the world Register at criticalcarereviews.com/meetings/ccr25
- Reposted by Chris NicksonThe third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU Register via the QR code or on the CCR website criticalcarereviews.com/meetings/ccr25
- Reposted by Chris NicksonThe fourth trial result for #CCR25 in Titanic Belfast in June is FLUID Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients Register at criticalcarereviews.com/meetings/ccr25
- Reposted by Chris NicksonThe fourth trial result for #CCR25 in Titanic Belfast in June is FLUID Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients Register at criticalcarereviews.com/meetings/ccr25 Critical Care Reviews Meeting 2025 The Best Critical Care trials in the World
- Reposted by Chris NicksonThe fifth trial result for #CCR25 in Titanic Belfast in June is NOTACS Nasal High-Flow Oxygen Therapy after Cardiac Surgery Register at criticalcarereviews.com/meetings/ccr25 Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World
- Reposted by Chris NicksonThe sixth trial result for #CCR25 in Titanic Belfast in June is PROMIZING Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Register at criticalcarereviews.com/meetings/ccr25
- Reposted by Chris NicksonThe 7th presentation at #CCR25 is the TTM2 biomarker results Biomarkers of Brain Injury after Cardiac Arrest Register via the QR code or on the CCR website Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World
- Reposted by Chris NicksonDelighted to announce the 8th trial results presentation for #CCR25 - ENCOMPASS. Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship Register via the QR code or on the CCR website #CCR25 - The Best Critical Care trials in the World
- Reposted by Chris NicksonThe ninth trial result for #CCR25 in Titanic Belfast in June is INdex CT-perfusion for the Neurological Determination of Death Investigators - Michaël Chassé & Jai Shankar Register at criticalcarereviews.com/meetings/ccr25
- Reposted by Chris NicksonThe 10th presentation at #CCR25 is RESCUE 3 Temporary Transvenous Diaphragm Pacing vs Standard of Care for Weaning From Mechanical Ventilation Register via the QR code or on the CCR website Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World
- Reposted by Chris Nickson🚨 Coming Soon at #CCR25 🚨 The #TTM2 Biomarker Study results! Fresh insights into neuroprognostication after cardiac arrest 🧠 How will this impact clinical practice? ➡️editorial & expert discussion 📺 Free livestream — but it’s better in person! 🔗 criticalcarereviews.com/meetings/ccr25
- Reposted by Chris Nickson🚨 NOTACS TRIAL Results at #CCR25 🚨 📍 18 🇬🇧🇦🇺🇳🇿hospitals 👥 Up to 1,280 pts 🎯 High-flow nasal therapy vs standard oxygen after cardiac surgery 🩺 Days alive & at home by D90 🤔 Can HFNT enhance recovery after heart surgery? 📺 Free livestream! 🔗 criticalcarereviews.com/meetings/ccr25
- Reposted by Chris Nickson#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com
- Reposted by Chris NicksonAugmenting enteral protein did not improve outcomes for critically ill patients compared with standard protein levels in the intensive care setting. #CCR25 @criticalcarereviews.com ja.ma/4kuYRxv
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- It’s happening now
- 🚨 12 Major Critical Care Trials 🚨 🌟 Global experts 🗣️ Live discussion 📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡 🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪 🔗 criticalcarereviews.com/meetings/ccr25
- Anyone who met Rinaldo Bellomo remembers every second of it - he was incredibly warm, selfless, enthusiastic, and inspiring. Although clearly a “numbers” person - a titanic Atlas-like figure holding the world of ICU research on his shoulders - he was first and foremost a “people” person. Vale.
- Reposted by Chris NicksonThe BJA is deeply saddened by the passing of Professor Rinaldo Bellomo. A leading figure in critical care research, his contributions have had a lasting impact on the field. We extend our sincere condolences to his family, colleagues & the global critical care community.
- Reposted by Chris NicksonMy first post on Bluesky is my saddest - saying goodbye to a legend of the ICU world. Rinaldo's enthusiam, passion and drive for ICU research was second to none. A mentor & friend to so many of us.
- Vale Rinaldo Bellomo. www.linkedin.com/posts/anzics...
- Reposted by Chris NicksonRACP marks the loss of a giant in medical research: It is with great sadness we acknowledge the death of Professor Rinaldo Bellomo AO, one of the most visionary and influential clinician-scientists of our time, who passed away on Tuesday following a short illness. racp.edu.au/news-and-eve...
- Reposted by Chris NicksonWe are deeply saddened by the passing of Prof. Rinaldo Bellomo — a pioneer in critical care nephrology, a brilliant mind, and a generous mentor. His legacy will live on through the countless intensivists he inspired and the lives his work transformed. Our thoughts are with his loved ones.
- Reposted by Chris NicksonVale Rinaldo Bellomo. www.linkedin.com/posts/anzics...
- Reposted by Chris NicksonMost excellent I have to say #Ansky
- Chest drains and suction | INTENSIVE - excellent 7min animated talk-through of chest drains, underwater seals, and suction by Dr Ken Hoffman #FOAMed #FOAMcc intensiveblog.com/chest-drains...
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- Chest drains and suction | INTENSIVE - excellent 7min animated talk-through of chest drains, underwater seals, and suction by Dr Ken Hoffman #FOAMed #FOAMcc intensiveblog.com/chest-drains...
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- Still time to apply!
- Come join the 2025 Clinician Educator Incubator! EOIs close Feb 10th 2025. The Incubator is an Australia & NZ-based, critical care-focused, learning community for interprofessional Clinician Educators. Help lead critical care education in the 21st century. litfl.com/come-join-th...
- Very sad news indeed - vale Dr David Crippen.
- Come join the 2025 Clinician Educator Incubator! EOIs close Feb 10th 2025. The Incubator is an Australia & NZ-based, critical care-focused, learning community for interprofessional Clinician Educators. Help lead critical care education in the 21st century. litfl.com/come-join-th...
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- Reposted by Chris Nickson@criticalcarereviews.com Congratulations to the newly announced PROFESSOR Rob MacSweeney. Richly deserved for a modest person who works tirelessly in support of improving care of the critically ill through world leadership and creativity for clinical research dissemination with real impact. 👏 Prof.
