Donner Lab
The goal of our research is to understand how brain states shape decision-making, and how this process goes awry in certain neurological & psychiatric disorders
| tobiasdonner.net | University Medical Center Hamburg-Eppendorf, Germany
- 🚨New preprint on @biorxivpreprint.bsky.social: “Competing Neural Decision Variables in Human Frontal Cortex Shape Decision Confidence” by Alessandro Toso, @ayeletarazi.bsky.social, @jrochav.bsky.social, @ktsetsos.bsky.social & Tobias H. Donner 🔗 www.biorxiv.org/content/10.1...
- ⚖️ It has long been held that decisions result from a competition between neural populations encoding different choices. Yet, several technical challenges have so far precluded the direct observation of this so-called neural race🏃
- While the choice is only dictated by the winning neural population, theoretical considerations indicate that also (or only) the losing population should shape the internal sense of confidence associated with the decision.
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View full thread✨ This provides key new experimental constraints for mechanistic models of decision and confidence formation. Our results open a new window on the distributed neural dynamics underlying important subjective states such as confidence.
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- ⚖️ It has long been held that decisions result from a competition between neural populations encoding different choices. Yet, several technical challenges have so far precluded the direct observation of this so-called neural race🏃
- While the choice is only dictated by the winning neural population, theoretical considerations indicate that also (or only) the losing population should shape the internal sense of confidence associated with the decision.
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View full threadIt fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
- Reposted by Donner Lab🧠✨ Exciting new research alert! ✨🧠 Did you know that catecholamines can reduce choice history biases in perceptual decision-making? 🧐🔍 Paper: journals.plos.org/plosbiology/... With @donnerlab.bsky.social and @swammerdamuva.bsky.social
- How do catecholamines like #noradrenaline influence perceptual #DecisionMaking? @degeelab.bsky.social @donnerlab.bsky.social &co show that higher #catecholamine levels reduce individual choice history biases by dampening bias in the accumulation of sensory evidence @plosbiology.org 🧪 plos.io/4mMmNNX
- Reposted by Donner LabHow do catecholamines like #noradrenaline influence perceptual #DecisionMaking? @degeelab.bsky.social @donnerlab.bsky.social &co show that higher #catecholamine levels reduce individual choice history biases by dampening bias in the accumulation of sensory evidence @plosbiology.org 🧪 plos.io/4mMmNNX
- 1/ New paper on @ScienceAdvances: Large-Scale Maps of Altered Cortical Dynamics in Early-Stage Psychosis Are Related to GABAergic and Glutamatergic Neurotransmission (www.science.org/doi/10.1126/...).
- 2/ Psychotic disorders, such as schizophrenia, present a major challenge for research and clinical practice: their pathogenesis is complex, the individual symptomatology is heterogenous, and there is a lack of biomarkers for early diagnosis.
- 3/ Properties of cortical circuits, such as the ratio between synaptic excitation and inhibition, vary across the cerebral cortex and are altered in psychosis. These properties are reflected in spontaneous neural population dynamics that can be mapped with high precision using MEG.
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View full thread13/ This work was led by @ayeletarazi.bsky.social, with Alessandro Toso, and our collaborators Tineke Grent-‘t-Jong and Peter Uhlhaas.
