Iván Darío Bravo Tobar. M.D. | M.Sc. | Ph.D.
"Science isn't just a job, it's the passion for transforming knowledge into impact."
Physician 🏷️ Academic 🏷️ Clinical Biomedical & Translational Research 🏷️Medical & Scientific Writing 🏷️ Consultant 🏷️ Amateur astronomer.
#MedSky #SciSky #BioChemSky
- Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-randomised controlled trial - The Lancet Primary Care www.thelancet.com/journals/lan...
Effectiveness of a guideline implementation tool for supporting management of mental health complications after mild traumatic brain injury versus usual care in primary care: a triple-blind, cluster-r...
The guideline implementation tool designed for proactive management of mental health complications after mild traumatic brain injury did not result in clinically meaningful reductions in the risk of m...thelancet.com Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway - Scientific Reports
Scientific Reports - Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathwaynature.comChildhood Physical Fitness as a Predictor of Cognition and Mental Health in Adolescence: The PANIC Study - Sports Medicine
Background Cognitive and mental health problems are highly prevalent in adolescence. While higher levels of physical fitness may mitigate these problems, there is a lack of long-term follow-up studies...link.springer.comRole of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity, and impulsivity. Although its precise etiology remains unclear, current evidence suggests that ...pmc.ncbi.nlm.nih.govA systematic review on type 3 diabetes: bridging the gap between metabolic dysfunction and Alzheimer’s disease - Diabetology & Metabolic Syndrome
Background Alzheimer’s disease (AD) is increasingly associated with metabolic dysfunction, particularly insulin resistance, which impairs neuronal signaling and energy metabolism. Disruption of brain ...link.springer.com- Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts - The Lancet Respiratory Medicine www.thelancet.com/journals/lan...
Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts
Common and rare genetic variation confer context-specific genetic risk in patients with IPF both competitively and cooperatively. In contrast to known IPF common risk variants, the telomere length PRS...thelancet.com - Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study - The Lancet Digital Health www.thelancet.com/journals/lan...
Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational st...
Our findings reveal that larger stroke lesions are associated with accelerated ageing in the ipsilesional hemisphere and paradoxically decelerated brain ageing in the contralesional hemisphere, sugges...thelancet.com - Full article: Fermented Moringa oleifera leaves and Ganoderma lucidum mixtures ameliorate cognitive deficits in scopolamine-induced dementia rats by enhancing brain antioxidant and cholinergic functions www.tandfonline.com/doi/full/10....
Fermented Moringa oleifera leaves and Ganoderma lucidum mixtures ameliorate cognitive deficits in scopolamine-induced dementia rats by enhancing brain antioxidant and cholinergic functions
Moringa oleifera Lam. (Moringaceae) and Ganoderma lucidum (Curtis) P. Karst. (Ganodermataceae) are two natural resources with established neuroprotective properties. However, whether their combinat...tandfonline.com Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancer - Scientific Reports
Scientific Reports - Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancernature.com- Not just a pain in the bone | Science www.science.org/doi/10.1126/...
Not just a pain in the bone
Growth factors secreted by sensory nerves promote fracture healingscience.org Little red dots as young supermassive black holes in dense ionized cocoons - Nature
The highest-quality JWST spectra reveal that little red dots are young supermassive black holes shrouded in dense cocoons of ionized gas, where electron scattering, not Doppler motions, broadens ...nature.com- Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH: Cell Metabolism www.cell.com/cell-metabol...
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH
Di Pastena et al. report that EVT0185, a dual ACLY/ACSS2 inhibitor, improves insulin sensitivity and steatosis while reducing fibrosis in MASH. By inhibiting acetate-driven cholesterol biosynthesis, w...cell.com Frontiers | Network pharmacology-based insights into the role of gut microbiota metabolites in insulin resistance
BackgroundExtensive research has demonstrated that the gut microbiota plays a critical role in maintaining homeostasis and promoting overall human health. Ho...frontiersin.orgTreatment of Refractory Syndrome of Inappropriate Antidiuresis With Sodium-Glucose Cotransporter-2 Inhibitor
The objective of this report is to describe a patient with syndrome of inappropriate antidiuresis (SIAD) who was successfully treated with empaglifloz…sciencedirect.com- Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome url: academic.oup.com/jcem/article...
Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome
AbstractBackground. Polycystic ovary syndrome (PCOS) is associated with adverse clinical outcomes that may differ according to PCOS phenotype.Methods. Usinacademic.oup.com - Dopamine and Mood in Psychotic Disorders url: jamanetwork.com/journals/jam...
Dopamine and Mood in Psychotic Disorders
This cross-sectional study uses fluorine F 18–labeled fluorodopa (18F-DOPA) positron emission tomography (PET) to test for differences in dopamine synthesis capacity between affective syndromes across...jamanetwork.com Early detection of mental health disorders using machine learning models using behavioral and voice data analysis - Scientific Reports
Scientific Reports - Early detection of mental health disorders using machine learning models using behavioral and voice data analysisnature.comAssociation of British Neurologists (ABN) autoimmune myasthenia gravis management guidelines (2025 update)
The 2025 update of the Association of British Neurologists guidelines for the management of autoimmune myasthenia gravis (MG) emphasises several points that are distinct from the 2015 guidelines based...pn.bmj.com- Monogenic cerebral small‐vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology - Mancuso - 2020 - European Journal of Neurology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
Monogenic cerebral small‐vessel diseases: diagnosis and therapy. Consensus recommendations of the European Academy of Neurology
Background and purpose Guidelines on monogenic cerebral small-vessel disease (cSVD) diagnosis and management are lacking. Endorsed by the Stroke and Neurogenetics Panels of the European Academy of N...onlinelibrary.wiley.com Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma - Nature Cancer
McGrail and colleagues report that high intratumoral bacteria abundance is associated with an immunosuppressive microenvironment and resistance to immune checkpoint blockade in head and neck squamous ...nature.com- Peripheral Neuropathy: A Review url: jamanetwork.com/journals/jam...
Peripheral Neuropathy: A Review
This review discusses the pathophysiology, clinical presentation, diagnosis, and treatment of length-dependent peripheral neuropathy.jamanetwork.com Bundled measurement of LDL-cholesterol, lipoprotein(a), and high sensitivity C-reactive protein across the spectrum of cardiovascular risk
In the era of the Predicting Risk of Cardiovascular Disease (CVD) EVENTs (PREVENT) equations, recalibrating definitions for low, borderline, intermedi…sciencedirect.com- Predatory journals: what can we do to protect their prey? - The Lancet www.thelancet.com/journals/lan...
Predatory journals: what can we do to protect their prey?
A growing number of entities misrepresent themselves as scholarly journals for financial gain despite not meeting scholarly publishing standards.1,2 As editors and members of the International Committ...thelancet.com - Definition and diagnostic criteria of clinical obesity - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...
Definition and diagnostic criteria of clinical obesity
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approa...thelancet.com - Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | Science www.science.org/doi/10.1126/...
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal
Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...science.org - Natural daylight during office hours improves glucose control and whole-body substrate metabolism: Cell Metabolism www.cell.com/cell-metabol...
Natural daylight during office hours improves glucose control and whole-body substrate metabolism
Harmsen et al. compared the metabolic impact of natural daylight vs. artificial office lighting in individuals with type 2 diabetes over 5 days. Daylight improved glucose homeostasis, whole-body fat u...cell.com Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons - Translational Psychiatry
Translational Psychiatry - Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neuronsnature.com- Targeting γδ T cells for immunotherapies against colorectal cancer: Trends in Immunology www.cell.com/trends/immun...
Targeting γδ T cells for immunotherapies against colorectal cancer
The advancement of immunotherapy faces significant challenges, including extending its benefits to a growing number of patients and enhancing its efficacy across different tumor types. In this context...cell.com - Polarized Signatures of the Earth Through Time: An Outlook for the Habitable Worlds Observatory doi.org/10.3847/1538... via @ioppublishing.bsky.social
Polarized Signatures of the Earth Through Time: An Outlook for the Habitable Worlds Observatory
Polarized Signatures of the Earth Through Time: An Outlook for the Habitable Worlds Observatory, Goodis Gordon, Kenneth E., Karalidi, Theodora, Bott, Kimberly M., Wogan, Nicholas F., Arney, Giada N., ...doi.org A joint complex network and machine learning approach for the identification of discriminative gene communities in autistic brain
Autism is a genetically and clinically very heterogeneous group of disorders. Gene co-expression network analysis can help unravel its complex genetic architecture through the identification of commun...journals.plos.org- Targeting H3N2 influenza: advancements in treatment and vaccine strategies: Expert Review of Anti-infective Therapy: Vol 23, No 1 www.tandfonline.com/doi/abs/10.1...
Targeting H3N2 influenza: advancements in treatment and vaccine strategies
The emergence of the H3N2 influenza virus in 1968 marked a significant event as it crossed the species barrier. This shift led to a pandemic, resulting in the deaths of one million people globally ...tandfonline.com Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants - BMC Psychology
Background Prenatal anxiety, prenatal depression, and pregnancy-related stress are prevalent among pregnant women. Across China, the prevalence rates of antenatal depression, anxiety, and pregnancy-re...link.springer.comAdvancements in prenatal diagnosis and management of hypoplastic left heart syndrome: A multidisciplinary approach and future directions
Hypoplastic left heart syndrome is a severe congenital defect involving underdeveloped left-sided cardiac structures, leading to significant mortality and morbidity. Prenatal diagnosis using fetal ultrasound and echocardiography enables early ...pmc.ncbi.nlm.nih.govAssociation of Heart Rate Variability with Postnatal Maturation in Preterm Infants
Abstract. Introduction: We assessed whether longitudinal measurements of sample entropy (SampEn) of heart rate time series reflect postnatal maturation in preterm infants and evaluated its predictive ...karger.comFrontiers | Association of high consumption of soy products with the risk of cognitive impairment and major neurocognitive disorders: a systematic review and dose-response meta-analysis
ObjectiveWhile soy products can potentially affect cognitive function through various mechanisms, the dose-response connection of high soy consumption with m...frontiersin.org- Vitamin-Mediated Glucose Flow Cell for Sustainable Power Generation | ACS Energy Letters pubs.acs.org/doi/10.1021/...
Vitamin-Mediated Glucose Flow Cell for Sustainable Power Generation
Glucose as a biofuel offers unique advantages, including low-temperature electricity generation, easy accessibility, low storage cost, and adaptability for on-demand power generation. Riboflavin, comm...pubs.acs.org An In-depth overview of artificial intelligence (AI) tool utilization across diverse phases of organ transplantation - Journal of Translational Medicine
Artificial Intelligence (AI) offers a revolutionary approach to improve decision-making in medicine through the use of advanced computational tools. Its ability to analyze large and complex datasets e...link.springer.comTinnitus risk factors and its evolution over time - Nature Communications
Improving tinnitus prevention and clinical management by identifying key associated risk factors is crucial. Here, the authors use machine learning in a large cohort to identify key predictors of tinn...nature.com- Warm, water-depleted rocky exoplanets with surface ionic liquids: A proposed class for planetary habitability | PNAS www.pnas.org/doi/full/10....
Warm, water-depleted rocky exoplanets with surface ionic liquids: A proposed class for planetary habitability | PNAS
The discovery of thousands of exoplanets and the emergence of telescopes capable of exoplanet atmospheric characterization have intensified the sea...pnas.org Disease-specific B cell clones are shared between patients with Crohn’s disease - Nature Communications
Perturbed B cell responses have been associated with Crohn’s disease. Here, the authors sequence the B cell receptor repertoire in patients with Crohn’s disease and identify shared B cell clones, thus...nature.com- Post‐Cholecystectomy Pancreatitis When Zero Means Lethal: Fulminant Post‐Cholecystectomy Pancreatitis Following a Benign Initial Ranson Score—A Case Report - Bibi - 2025 - Clinical Case Reports - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Post‐Cholecystectomy Pancreatitis When Zero Means Lethal: Fulminant Post‐Cholecystectomy Pancreatitis Following a Benign Initial Ranson Score—A Case Report
Post-cholecystectomy pancreatitis (PCP) represents a rare yet potentially lethal iatrogenic complication whose clinical management is frequently undermined by an insidious progression and the fallibi...onlinelibrary.wiley.com Melanin-like nanofibers with highly ordered structures achieve ultrahigh specific electromagnetic interference shielding efficiency - Nature Communications
Lightweight electromagnetic shielding materials are of interest, though it is challenging to balance performance and processability with conventional materials. Here, the authors report, an ordered me...nature.com- Full article: Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation www.tandfonline.com/doi/full/10....
Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation
Sympathetic overactivity is closely associated with vascular remodeling. Sympathetic fibers dominantly innervate the adventitia of arteries rather than tunica media. Vascular adventitial fibroblast...tandfonline.com Discovery of odd radio circles and other peculiars in the first year of the EMU survey using object detection | Publications of the Astronomical Society of Australia | Cambridge Core
Discovery of odd radio circles and other peculiars in the first year of the EMU survey using object detection - Volume 42cambridge.org- Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
A Contrast‐Agnostic Method for Ultra‐High Resolution Claustrum Segmentation
The claustrum is a still poorly understood structure, with limited neuroimaging tools available for its study. Here we propose a method for automatic claustrum segmentation at ultra-high resolution (...onlinelibrary.wiley.com Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategiesnature.comOort cloud ecology - III. The Sun’s departure from the parent star cluster shortly after the giant planets formed | Astronomy & Astrophysics (A&A)
Astronomy & Astrophysics (A&A) is an international journal which publishes papers on all aspects of astronomy and astrophysicsaanda.orgFunctional significance of cholesterol metabolism in cancer: from threat to treatment - Experimental & Molecular Medicine
Emerging evidence suggests that changes in cholesterol metabolism can be involved in the onset and progression of cancer, opening avenues towards better understanding of cancer and new treatment optio...nature.comA computational fluid dynamics analysis of BiPAP pressure settings on airway biomechanics using a CT-based respiratory tract model
Central and Obstructive Sleep Apnea (CSA and OSA), Chronic Obstructive Pulmonary Disease (COPD), and Obesity Hypoventilation Syndrome (OHS) disrupt br…sciencedirect.com- Research Progress of Biomarkers for Sepsis and Precision Medicine - Wang - 2025 - Emergency Medicine International - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Research Progress of Biomarkers for Sepsis and Precision Medicine
Since 1989, the definition of sepsis has been revised several times. The 2016 Sepsis-3 consensus definition of sepsis aims to improve diagnostic accuracy and reduce the frequency of misdiagnosis. The....onlinelibrary.wiley.com
