Christian Wunder @ Curie Institute

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  Tom Robinson tomrobinson.com · Feb 22, 2025
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  Christian Wunder @ Curie Institute handle.invalid · Feb 22, 2025
  Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis. => A proton pump driven glycoswitch @naturecellbiology.bsky.social : rdcu.be/eaLM9 #glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
  
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  Christian Wunder @ Curie Institute handle.invalid · Feb 22, 2025
  ... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...
  

  Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate

  Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...

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