Andrew Grotzinger
Assistant Professor at CU Boulder interested in multivariate genomic methods development and their application to understanding shared and unique signal across human disease and risk factors.
- Reposted by Andrew GrotzingerAnalysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3Ymtiwg
- Reposted by Andrew GrotzingerScientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? go.nature.com/48AooC4
- Want to echo Abdel and encourage reading this excellent commentary he put together!
- For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
- Reposted by Andrew GrotzingerFor more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
- 1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
- 1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
- 2/4 We triangulated across methods (Genomic SEM; LAVA; MiXeR; CC-GWAS) and levels of analysis (genome-wide -> functional -> local -> locus) to identify five subsets of disorders (e.g., depression, PTSD, anxiety) with particularly high genetic overlap and few pathways or loci that differentiate them.
- 3/4 In line with high psychiatric comorbidity, this suggests biological boundaries across some disorders are fuzzy at best. Notable findings include genes expressed in excitatory neurons in fetal and adult datasets tagging shared signal across bipolar and schizophrenia (but see paper for many more!)
- 4/4 A HUGE 🙏thank you to the @pgcgenetics.bsky.social working groups and participants and amazing co-authors, with special shoutout to Josefin Werme, Wouter Peyrot, Alex Frei, Christiaan de Leeuw, Lucy Bicks, Ken Kendler, and @jorsmo.bsky.social. This work reflects collaboration at its best ❤️🧬
- Reposted by Andrew GrotzingerIBG is saying a fond farewell to former postdoc @isyfoote.bsky.social. Isy was an invaluable asset to the institute in her time here. She is a Wellcome Trust Fellow and new faculty Queen Mary University of London. We can't wait to see what comes next for this exceptionally bright scholar 🧠🧬!
- I'm delighted to say that, as of yesterday, Dr. Isy Foote @isyfoote.bsky.social is now my former postdoc as she is staring a faculty position at Queen Mary University of London. Isy is starting the position with a Wellcome Trust Fellowship 🏆. I couldn't be prouder and she will be sorely missed! ❤️
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- Reposted by Andrew GrotzingerUniversity of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...
- Reposted by Andrew GrotzingerUniversity of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!! jobs.colorado.edu/jobs/JobDeta... #socialpsychology #cogpsyc #PsychSciSky #PsychJob #psycjobs #psychology 1/n
- Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
- New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...
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- Reposted by Andrew GrotzingerCheck out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...
- Reposted by Andrew GrotzingerExtremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
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- One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!
- You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...
- GNA estimates conditional genetic associations across traits, SNPs, or genes. In an empirical application, we show that a GWAS of Type 2 Diabetes implicates broad pathways (e.g. chemical reactions in the body) whereas SNP-level GNA results pinpoint core disease processes (e.g. insulin secretion) 2/2
- Reposted by Andrew GrotzingerNew preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
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- 🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)
- Students in my lab have an interest in at least one of the research areas listed above, but are not required to engage in research in all areas. Information on how to apply can be found here. Due date for applications is November 15th. www.colorado.edu/psych-neuro/...
- Here's a picture of my current lab (graduate students Luke Schaffer, Jeremy Lawrence, Sophie Breunig and my postdoc Dr. Isy Foote). We are a collaborative, productive, and nice group and I hope you'll consider joining us!
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