César de la Fuente
Presidential Associate Professor @upenn.edu - using AI to reimagine antibiotic discovery and peptide design. Previously @MIT, @UBC
🔗 https://delafuentelab.seas.upenn.edu
- Thank you for the very inspiring visit! Incredible work being done @stowersinstitute.bsky.social
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- Gracias a Esther Molina por destacar nuestro trabajo con @basecamp-research.bsky.social y NVIDIA. EDEN muestra cómo los modelos evolutivos de IA pueden escalar la inserción génica y abordar la resistencia a los antimicrobianos. www.elespanol.com/invertia/dis....
- Thank you @biotechniques.bsky.social for the opportunity to discuss how AI is changing the way we mine biology for new therapeutics. I enjoyed sharing our lab’s work using advanced AI models to expand the search space for novel antibiotics, especially as antimicrobial resistance continues to rise.
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- Reposted by César de la FuenteHow combining AI with genetic databases can harness lessons from evolution to develop new diseases treatments. An international collaboration using information from more than 1mn species offers potential solutions to problems from cancers to drug-resistant superbugs. www.ft.com/content/29ec...
- Thrilled to share EDEN — a DNA-scale foundation model built with @basecamp-research.bsky.social + NVIDIA partly validated by our lab @upenn.edu . Trained on 1M+ new species, it designs novel antibiotics with 97% success. Biodiversity at scale = models that generalize and design. bit.ly/3NpMR4B
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- What every microbiologist should know about AI New Microbial Primers article with Hanqun Cao in @microbiologysociety.org’s Microbiology is out now! bit.ly/3NvutY4
- Our latest piece's out in @cp-cellbiomat.bsky.social @cellpress.bsky.social . In this review, we explore how AI can power cancer nanomedicine—from smart nanoparticle design to clinical translation—toward truly personalized, precision-matched therapies. www.sciencedirect.com/science/arti...
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- 🎄The de la Fuente Lab wishes you happy holidays and a joyful, healthy, and inspiring 2026! Thank you for being part of our journey as we continue pushing science forward—together.
- Gracias, @vozdegalicia.bsky.social, por este artículo sobre nuestro último modelo de IA, ApexAmphion, que aprende como los humanos para vencer a las superbacterias. www.lavozdegalicia.es/noticia/soci...
- Gracias a Diego Domingo y @consalud.bsky.social por destacar nuestro trabajo con KCM: una IA para diseñar proteínas de forma rápida, accesible y sin supercomputadoras. Un paso más en la lucha contra las superbacterias. www.consalud.es/profesionale...
- Incredible honor to receive an Honorary Doctorate from University of León at 39. This recognition belongs to my amazing team, working tirelessly to discover new antibiotics with AI to fight one of the greatest threats facing humanity: antimicrobial resistance. www.unileon.es/noticias/el-...
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- Emocionado y agradecido por recibir el doctorado Honoris Causa de la Universidad de León a los 39 años. Este honor es para mi equipo, que usa IA para acelerar el descubrimiento de antibióticos y luchar contra las superbacterias. 🧬🎓 www.unileon.es/noticias/el-...
- Absoluta maravilla esta conversación con mi amigo @pablofuente.com y una de las mejores científicas del planeta Eva Nogales de @ucberkeleyofficial.bsky.social! www.youtube.com/watch?v=LB-1...
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- AI is transforming antibiotic discovery. My talk “AI for Antibiotic Discovery” is now live on The Biomedical & Life Sciences Collection—sharing our lab’s latest work and what’s next at the AI–microbiology frontier. 🧬🤖 🎧 hstalks.com/t/10090/ai-f...
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- Thanks to @NatureBiotech for featuring our latest piece, co-authored with the fantastic Yumeng Zhang and Jiangning Song.
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- Absoluta maravilla esta conversación con mi amigo @pablofuente.com y una de las mejores científicas del planeta @nogaleslab.bsky.social @ucberkeleyofficial.bsky.social!
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- Excited to be visiting @psumbiome.bsky.social on December 5 to give a lecture! Looking forward to engaging with students and faculty — see you there! www.psu.edu/news/huck-in...
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- Honored to join the #VinFuturePrize Science for Life Symposia panel on AI Ethics & Safety for Humanity with brilliant minds like Hinton, @yoshuabengio.bsky.social, Valiant, Cerf, Luu, Prestes & @tobywalsh.bsky.social. Grateful to help shape the global AI ethics conversation. 🌍🤖
- Thank you @asm.org for inviting me to the first ASM event in India. The IISc Global Research Symposium on the One Health Approach to Antimicrobial Resistance was a powerful example of what’s possible for AMR research there. The scientific talent here is extraordinary—excited to see what comes next.
- It’s an honor and a privilege to be included in the 2025 #FuturePerfect25 list, which celebrates the fight for a healthier, fairer future. I’m humbled to be part of this ambitious project from @voxdotcom.bsky.social and in the company of so many changemakers I revere. www.vox.com/future-perfe...
- Honored to be recognized once again among the top 1% of the world’s most highly cited researchers by @clarivate.com. This is a testament to the relentless curiosity and hard work of my team. Grateful for their dedication to pushing the frontiers of science.
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- ¡Gracias por la entrevista! Fue un placer hablar con @farodevigo.es sobre el trabajo de mi laboratorio. Galicia tiene una oportunidad única para convertirse en un foco de biotecnología y de IA. Un auténtico placer estar de vuelta en nuestra preciosa tierra.
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- Spoke at @elrig.org SCIENCE in Liverpool about moving faster on antibiotics with AI and high-qualiy training data. Amazing community. The energy in the room was the best part. You’ll Never Walk Alone.
- Grateful to Elizabeth Stivison for covering our work with superstars Marcelo Torres and Anna Crysler on training AI to uncover novel antibiotics in @asbmb.bsky.social Today! Excited to see growing momentum at the intersection of AI and antibiotic discovery.
- Very much looking forward to it!
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[Not loaded yet] - Thank you @microbiologysociety.org for featuring our new article “Artificial intelligence for microbiologists”, a practical primer for anyone in microbiology wanting to get started with AI and ML. Led by superstar PhD student Hanqun Cao.
- 🎙️ Honored to take part in EIRNABio’s “10 Questions” — discussing AI-driven antibiotic discovery, the future of digital biology, and what inspires my journey.💡🔬 eirnabio.com/10-questions...
- Thank you Bob Service for highlighting in @science.org our work using AI to uncover antibiotics from archaea. Grateful for the thoughtful coverage—and excited by growing interest in these ancient microbes, a distinct branch of the tree of life.
- Huge thanks to @nikomccarty.bsky.social and the @asimovpress.bsky.social Podcast for the incredible gift—a book encoded in DNA! 🧬📖 A beautiful fusion of science, art, and storytelling.
- 🎥 Proud to share my @upenn.edu Penn Today video, “Uncovering New Antibiotics with AI.” See how AI is helping us find tomorrow’s antibiotics—today. Watch: penntoday.upenn.edu/news/uncover...
- En mi charla de Frontiers in Genomics de UNAM MX exploro cómo la IA puede transformar el descubrimiento de antibióticos: de la minería de datos a la biología digital. 💡🔬 ¡No te la pierdas! 👉 www.youtube.com/watch?app=de...
- Science runs on curiosity… and cookies. 🍪🧪 Thanks The Scientist for spotlighting our “Cookie Wednesday,” a sweet way to fuel cross-disciplinary creativity. www.the-scientist.com/scientists-s...
- My friend #EltonBrand @sixersnba.bsky.social and I at my lab's Halloween party talking about the future of AI and Sports. What are your thoughts? Do you think #RudyFernandez and #SergeiIbaka would approve of our costumes?😉 Wishing everyone a Happy Halloween! 🎃
- Big day at @upenn.edu ! Honored to host my friend Elton Brand from @sixersnba.bsky.social for a deep dive into how we’re using AI to fight antimicrobial resistance. Thanks for the sharp questions and team spirit, Elton! 🧪🏀
- It was an honor to participate in the third course organized by @mobilise.bsky.social @i3suporto.bsky.social, sharing experiences with incredible people. A privilege to learn, share, and connect with such an amazing group.
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- 1/5 Today we are introducing the Key-Cutting Machine (KCM) for protein and peptide design. Like cutting a key to fit a lock, KCM sculpts sequences to match a target backbone—on a single GPU. No retraining. No clusters. 🧬🔑
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- Grateful to @scifri.bsky.social for inviting me to share our latest work using AI to identify new antibiotics in archaea by digitally mining its genetic code. Huge thanks to @heyira.bsky.social for a wonderful conversation!
- 🧬 Today we introduce Key-Cutting Machine (KCM)—an AI tool that designs proteins like cutting a key to fit a lock. Runs on 1 GPU. No retraining. No clusters. Precise, accessible, and tested in vivo. Now in @natmachintell.nature.com 🧠🔑 @natureportfolio.nature.com www.nature.com/articles/s42...
- Thrilled to be part of this paper in npjAMR @natureportfolio with William J. Waldock, Hannah Thould, Leonid Chindelevitch, Nicholas J. Croucher, James J. Collins, Hutan Ashrafian & Ara Darzi! We tackle AMR globally and explore AI-driven solutions. www.nature.com/articles/s44...
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- AI could reshape infectious disease control end-to-end—from faster outbreak detection to smarter diagnostics—but progress is constrained by data. My @thelancetinfdis.bsky.social @thelancet.com article lays out how to break the bottleneck responsibly. www.thelancet.com/journals/lan...
- Thank you so much for having me. It was wonderful to be back @i3suporto.bsky.social in beautiful Porto—my first time since childhood. Fantastic friends and science all around!
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- Thank you so much for highlighting our latest work!
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- En España mueren más de 4.000 personas al año por infecciones resistentes a los antibióticos. Urge innovar, sensibilizar y actuar. Gracias COPE por difundir nuestras últimas investigaciones. 🎙️🔬 www.cope.es/programas/he...
