Daniel De Carvalho
- Ten years ago, we discovered that reactivating transposable elements triggers an antiviral state in cancer cells, a process we named viral mimicry, unmasking tumors to the immune system (Roulois, Cell 2015).
- This week, that idea reached patients: Viral-mimicry priming + anti-PD-1 in relapsed/refractory NK/T-cell lymphoma delivered 47.6% complete responses, 66.7% ORR, and ~50% 2-year OS, even after prior PD-1 failure (Huang, Cancer Discovery 2025).
- Thrilled to see a basic mechanistic discovery translate to meaningful clinical benefit! aacrjournals.org/cancerdiscov...
- Reposted by Daniel De CarvalhoWe are thrilled to have Daniel De Carvalho (@daniel-decarvalho.bsky.social) from Princess Margaret Cancer Centre / University of Toronto as our Keynote speaker at #EREHD25. What a way to close 3 days of wonderful science. Thank you for being with us in Mexico Daniel!
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- Excited to have this paper out today! Repeats mimic pathogen-associated patterns across a vast evolutionary landscape." It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others! www.cell.com/cell-genomic...
- We found that many transposons resemble pathogens to innate immune sensors, a property widespread across eukaryotes. Here, we formalized "viral mimicry" with a quantitative statistical physics framework, estimating selective forces that enrich pathogen-associated motifs beyond the genome background
- Reposted by Daniel De CarvalhoAre you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov! 🎙️Talk Submission extended to 03 Sept 💰Final few $500 grants remaining Don't Miss out! bit.ly/4eRq9Mp
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- Risky moves: Can blocking “jumping genes” treat diseases and aging? Great piece in Science Magazine highlighting recent efforts to understand and target transposons—also known as "jumping genes"—in human disease and aging.
- Thank you @gairdnerawards.bsky.social! I'm truly humbled and grateful for this recognition. Science is never a solo journey and this award reflects the hard work, creativity, and persistence of many amazing scientists I had the privilege to work with.
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- Reposted by Daniel De CarvalhoNew Links: Cancer and Immune Evasion Cancer cells without the tumor suppressor protein p53 become more resistant to the body's immune response and more likely to survive. A study led by Dr. Daniel De Carvalho at UHN’s Princess Margaret Cancer Centre. www.uhnresearch.ca/news/new-lin...
- Happy to see this paper out!
- Scientists @pmresearch-uhn.bsky.social have uncovered how cancer can evade immune defenses after losing a key tumour-suppressing gene. These findings implicate repetitive elements in DNA and may unlock new targets for cancer interception. Read more ➡️ www.uhnresearch.ca/news/new-lin...
- Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery: aacrjournals.org/cancerdiscov...
- It was a massive team effort led by @cishak.bsky.social during his postdoctoral fellowship in my group @pmresearch-uhn.bsky.social. Charles now leads his on lab @mdanderson.bsky.social
