- I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...
- 2) Biology works differently in the leptomeningeal space, which is why normal therapies fail there. Anti-tumor immunity is different: independently of antigen presentation: Interferon gamma drives maturation of dendritic cells into supporters of NK cell-mediated tumor killing ->May 14, 2025 15:57
- 3) Good computation played a role in deciphering this unique anti-tumor cell circuit. It required sophisticated factor based methods to find gene programs developed by @russellkunes.bsky.social and our psuedo-time algorithms which @meningojan.bsky.social expertly applied ->
- 4) Rigorous and basic science that elucidates how tumor immunology works in the leptomeningeal space can lead to better therapies for this lethal and debilitating metastatic site. Basic science matters!
- 5) To further clarify the full cell circuit see the image below: T cells produce IFNγ, supporting maturation of conventional DC2 cells into migratory CCR7+ DCs. These DCs produce IL-12 and IL-15 to support the survival and proliferation of NK cells, which control the expansion of metastatic cells.
