From the S. Shin lab
sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella.
doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation | mBio
Inflammasomes are essential for host defense against intracellular bacterial pathogens
like Legionella, as they activate caspases, which promote cytokine release and cell death to control
infection. I...
