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Thomas Henry
cinflammasome.bsky.social
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Researcher at CIRI, Lyon, France. Working on innate immune signalling pathways in autoinflammatory diseases and bacterial infections. Francisella and the type 6 secretion system Inflammasomes & ALPK1/TIFA pathway FMF, PAAND & ROSAH
Joined
November 2023
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Thomas Henry
cinflammasome.bsky.social
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Feb 2
IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab
@ciri-lyon.bsky.social
published in
@emboreports.org
. IRF2 as a key immune regulator against our favorite bug,
#Francisella
tularensis!
#inflammasome
link.springer.com/article/10.1...
IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports
IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...
link.springer.com
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