Junhong Choi
PI at MSKCC. Synthetic (Developmental) Biology + Molecular Recording + Genomics Tech Dev. Words like physicality of information make my heart go a little faster.
- Reposted by Junhong ChoiThrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
- Reposted by Junhong ChoiSuper excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...
- Reposted by Junhong Choi🎉 Congrats to MSK postdoc research scholar Dr. Brendan Camellato for being named a 2025 @jcchildsfund.bsky.social Research Fellow! His work will focus on how cell signaling drives #stemcell differentiation with single-cell resolution. #JCCFellow
- We're thrilled to announce the 2025 class of Jane Coffin Childs Fellows! See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research! www.jccfund.org/blog/the-jan... www.jccfund.org/wp-content/u...
- Congrats Brendan Camellato for his Jane Coffin Childs Fellowship!! 🎉🎉
- We're thrilled to announce the 2025 class of Jane Coffin Childs Fellows! See our latest blog post and "look book" to learn more about our newest Fellows and their exciting research! www.jccfund.org/blog/the-jan... www.jccfund.org/wp-content/u...
- Reposted by Junhong ChoiWe're thrilled to share the published version of our DRT9 story, online today @nature.com! Congratulations to all authors! www.nature.com/articles/s41...
- Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...
- New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
- We previously showed that DNA Typewriter can record high-resolution lineage trees in cultured cells (HEK293T). www.nature.com/articles/s41... But could we use it to study how clonal memory shapes cell fate decisions during development? (2/13)
- Mouse 3D gastruloids seemed like the perfect testbed—they mimic key features of early mammalian development in both shape and cell types. (Image from Turner @gastruloids.bsky.social & Martinez Arias @amartinezarias.bsky.social : doi.org/10.1002/bies...) (3/13)
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View full threadWe’re still thinking about what this means for actual embryonic development, but it’s exciting to observe such effects in a tractable stem-cell-derived model! Huge thanks to everyone in the @jshendure.bsky.social lab—especially Jay—for supporting this project from start to finish! (13/13)
- Very grateful to receive the Searle Scholars Award, especially during this challenging time! This support will help our lab realize our vision of genomic recording for reconstructing the mammalian cell fate decision. searlescholars.org/2025/04/14/s...
- Happy to share our new review on molecular circuits for genomic recording with @chenomics.bsky.social! Here, we present our views on the remaining challenges in the field of genomic recording for reconstructing cell-fate decisions. (1/2)
- Online now -- a new Review: "Molecular circuits for genomic recording of cellular events" by Wei Chen & Junhong Choi (@choijunhong.bsky.social) FREE to read till June 25th using this link: authors.elsevier.com/a/1l2gMcQbJF...
- We are very thankful to Jay Shendure @jshendure.bsky.social and the lab for fostering our views that led to this review, @cp-trendsgenetics.bsky.social for all their help, and the funding agencies (NHGRI, NCI, and @damonrunyon.org) that made this work (and our previous works) possible! (2/2)
- Reposted by Junhong ChoiTrying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1
- Reposted by Junhong ChoiNew year, new beginnings! 🎉 The Aviram Lab will officially open its doors on March 1st @mskcancercenter.bsky.social! We’ll study microbial immune systems and their connection to fundamental cellular processes like #RNA transcription and #DNA integrity. #NewPI #AcademicSky #WomenInSTEM (1/2)
- Reposted by Junhong ChoiOur latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...
- Reposted by Junhong Choi🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...
- Reposted by Junhong ChoiImagine a mouse in which all 10 billion cells keep a diary from fertilization. Imagine sentinel cells recording your experiences and sending out dispatches in the form of DNA. Here's a story I wrote about cell recorders 🧪 Gift link: nyti.ms/3Z3Mqza
- Pretty excited to see our review & DNA Typewriter covered by NY Times! Perhaps too much excitement for one Monday 🥲 www.nytimes.com/2024/11/25/s...
- Reposted by Junhong Choi"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing. www.nature.com/articles/s41...
- Reposted by Junhong ChoiThe latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
