Grant Challen

• 
  Grant Challen challenlab.bsky.social · Aug 1, 2025
  Check out our new paper describing a previously unexplored relationship between DNMT3A and telomeres. A huge team effort! Comments and new collaborations welcome!
  • 
    Cell Stem Cell handle.invalid · Jul 17, 2025
    Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity #stemcells
    

    Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity

    Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They identify non-canonical functions for Dnmt3a in the regulation of telomere length and genome stability that restrict the functional potential of HSCs.

    dlvr.it
  Repost Quote post

  View on BlueskyCopy Bluesky URLCopy post URLTranslate postShow all post labels
• 
  Grant Challen challenlab.bsky.social · Jul 25, 2025
  Pretty much every mid-40s dude tonight Let’s go Happy !!
  
  Repost Quote post

  View on BlueskyCopy Bluesky URLCopy post URLTranslate postDownload imageShow all post labels
• Reposted by Grant Challen
  
  Keisuke Ito keisukeito-lab.bsky.social · May 23, 2025
  Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
  

  Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis

  Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

  bit.ly
  Repost Quote post

  1

  View on BlueskyCopy Bluesky URLCopy post URLTranslate postShow all post labels