This is a large, ERC-scale initiative aimed at developing new methodologies for RNA modelling by integrating chemical probing data with state-of-the-art simulations. The applied focus will be on understanding the genome architecture of Influenza A, in close connection with experiment.

The project includes a strong link with Redmond Smyth (CNRS), whose expertise in virology and chemical probing will be central to integrating modelling with experimental virology.

A key component will be the further development and benchmarking of methods within @plumed.org , our community-driven platform for enhanced sampling and integrative molecular simulations, providing efficient high-performance workflows.