Brian Sweis
MD, PhD | psychiatry | neuroscience | neuroeconomics | neuromodulation | assistant professor | residency program training director @MountSinaiPsych @SinaiBrain 🧠
- Reposted by Brian Sweis🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky
- Reposted by Brian Sweis(1/6) We have a new paper out in #eNeuro! How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆 Read more: www.eneuro.org/content/12/1...
- Reposted by Brian Sweis1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Brian Sweis🚨 Reminder: Applications for #OptoGRC2026 are now OPEN! Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠 Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
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- Reposted by Brian SweisA Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
- For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
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✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡 www.biorxiv.org/content/10.1... 1/13 🧵 - Reposted by Brian SweisOur Behavioural Brain Research special issue on Ultrasonic Communication in Rodents is growing, rapidly – and actually a lot faster than I manage to post about it. Nine new manuscripts got accepted since my last post. Quite impressive work. Check it out: www.sciencedirect.com/special-issu...
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- For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
- Reposted by Brian Sweis"The way forward has become very clear"- Dr. Brendan G. Carr A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
- Reposted by Brian SweisWhen I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!
- Reposted by Brian SweisWe are also considering applications from undergraduate students and Master's students in the local New York City area! Please check out our website for more information on how to become involved: sinclaboratory.com/apply
- Reposted by Brian SweisOut today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
- Reposted by Brian Sweis🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging
- Reposted by Brian SweisExcited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026! @ubcpsych.bsky.social @dmcbrainhealth.bsky.social
- Reposted by Brian SweisWe're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
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- Reposted by Brian SweisThe Sosa Lab website is now live! www.sosaneurolab.com We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
- #FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬
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- Reposted by Brian SweisCheck out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
- Reposted by Brian Sweis🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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- Congrats Herbert and team!
- Super excited to share the first cooperative foraging paradigm in freely interacting mouse pairs! Stable leader and follower roles emerge spontaneously and predict learning. Well-trained mice show stereotyped, role-specific “behavioral motifs” absent in naive animals (1/5) doi.org/10.1101/2025...
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- Reposted by Brian SweisAbstract submission open for The Mechanistic Basis of Foraging 2025 (U. Birmingham, 3-5 November) uobevents.eventsair.com/the-mechanis... Deadline: August 17 A meeting for all fascinated by the brain's role in foraging Pls share!
- This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8
- New paper alert!🚨📝 Paper: tinyurl.com/2cycsy6d Press release: tinyurl.com/yur3j2n8 How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
- New paper alert!🚨📝 Paper: tinyurl.com/2cycsy6d Press release: tinyurl.com/yur3j2n8 How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
- Reposted by Brian SweisWhat’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope! Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals. Read the paper here: www.science.org/doi/10.1126/... (1/10)
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- Reposted by Brian Sweis"Science is an investment. We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world." — President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷
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- Love this 👏
- This is a super cool way of studying learning, effort, and foraging www.biorxiv.org/content/10.1...
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- Reposted by Brian SweisVery happy to share the latest from my postdoc! 10 yrs of mouse social networks + 1.25 yrs of acoustic data ➡️ insight into vocalization & sociality in a wild population of your favorite lab model 🐁 paper: bit.ly/4n93yyD data: bit.ly/4lfFBEk code: bit.ly/4kNnMwx #bioacoustics #neuroskyence 1/8
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- Reposted by Brian SweisMORE YOUNG: "It is palpably clear that these directives and the set of terminated grants here also are designed to frustrate, to stop, research that may bear on the health – we’re talking about health here, the health of Americans, of our LGBTQ community. That’s appalling."
- Reposted by Brian SweisYOUNG: "I am hesitant to draw this conclusion, but I have an unflinching obligation to draw it – that this represents racial discrimination. And discrimination against America’s LGBTQ community. That’s what this is. I would be blind not to call it out. My duty is to call it out."
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- Reposted by Brian SweisAn NIH staffer reacts to today's ruling: "I'm looking forward to the day that we are so slammed with work trying to reinstate everything that we had to terminate illegally — I'll work 24/7 to make that happen if I can."
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- Reposted by Brian SweisVery smart, high ROI initiative from the Spencer Foundation. Providing bridge funding for canceled NSF grants: 1) directs funds to projects already screened by a top-noch review process. 2) avoids imposing proposal prep costs on researchers. 3) ameliorates the disruption from GOP sabotage.
- Reposted by Brian SweisThe Baller Lab is thrilled to announce that @elenaccooper.bsky.social just had her first first-author publication! “Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol” is now published on BMJ Open: bmjopen.bmj.com/content/15/5/e094733! 🧠
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