Brennan Lab CVR
Lab Account | PI: @bbrennan83 | 🔬 bunyavirus/vector interactions at @CVRinfo.bsky.social🏴🇬🇧🇱🇹🇹🇭🇪🇺🏳️⚧️🏳️🌈
- Reposted by Brennan Lab CVRPre-print: our description of RZ affiliate ZNFX1 is now online. On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution. Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Brennan Lab CVR[Not loaded yet]
- 📢 Thrilled to share our NEW PREPRINT! SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠 🧫 NSs essential for tick but not mammalian infection 🧬 Binds 22-nt viral siRNAs to block RNAi 🕷️ Reveals host-specific viral immune evasion 📖 doi.org/p2vf #lovevirology #bunyavirus #tickborne
- Thread: How Viruses Hijack Tick RNA Machinery 🧬🕷️ Post 1/5 🧵 We just published the first map of how viruses rewire tick cell RNA machinery! Led by Alexandra Wilson & Wael Kamel! We Found 283 proteins that change RNA-binding during Uukuniemi virus infection. 📄 Our paper: doi.org/10.1371/jour...
- Post 2/5 🧵 METHOD: Using RNA interactome capture (RIC), we UV-crosslinks RNA-bound proteins to map the "RBPome" in infected vs healthy tick cells. Challenge: Bunyavirus RNA lacks poly(A) tails, yet found enough "poly(A)-like" sequences to capture viral RNAs too! #RNABiology #collaboration #Scitech
