Alex Chesler
Touch, pain and coffee
- Really enjoying sunny San Diego so far.
- Some news. Exciting new challenges and opportunities ahead.
- Reposted by Alex CheslerHave you seen the latest result from the Julius lab showing mitochondrial electron transport chains tuning as an intrinsic cellular strategy protecting nociceptors against excitotoxicity? Check out this #EditorsPick from @alexchesler.bsky.social now! bit.ly/46jodto #PRF
- Reposted by Alex CheslerThe latest papers published in pain research are now on PRF! Dr. Alex Chesler provides a curated list for Aug. 22-28, 2025 and a commentary on his pick for Paper of the Week! painresearchforum.org/paper @utdpaincenter.bsky.social @nyupainresearch.bsky.social @iasp.bsky.social @usasp.bsky.social
- Reposted by Alex CheslerSome very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...
- Sort of last minute but my group is looking to recruit a a recent college grad as postbac to start this summer and work on PIEZO channels. Project involves cell based assays, patch clamp recording, and imaging. Info on the NIH program can be found here: www.training.nih.gov/research-tra...
- Reposted by Alex CheslerVote today for SfN leadership! Ellen Lumpkin and Irene Tracey both there! www.directvote.net/SfN/
- Reposted by Alex CheslerThe last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for #painresearch at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share! heal.nih.gov/about/nih-he...
- Reposted by Alex CheslerRead this #PapersoftheWeek #EditorsPick from Ghitani et al. and @Nature.com demonstrating that nociceptor activity is both necessary and sufficient for inflammatory tactile allodynia bit.ly/4mcTuV4 #PRF
- Reposted by Alex CheslerThe feeling of a hug comes from the pressure and vibration of millions of nerve endings.
- Happy “May the 4th” or as I like to call it “Piezo Day”.
- Reposted by Alex CheslerHere’s just the most recent of the many NCCIH studies of #pain (from colleague @alexchesler.bsky.social published last week in Nature). Nearly 50% of NCCIH funding goes to studying pain, with a focus on nonpharmacological treatments and mechanisms. The proposed budget eliminates NCCIH.
- co-author @dimacd.bsky.social pointed out that the link was truncated in my post. Hope this works: www.nature.com/articles/s41...
- Reposted by Alex CheslerI am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
- Four old men from NYC. Reunited to see a punk band that I last saw live at CBGBs in high school. Friends for four decades.
- Reposted by Alex CheslerNice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
- An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...
- co-author @dimacd.bsky.social pointed out that the link was truncated in my post. Hope this works: www.nature.com/articles/s41...
- Huge congratulations to the always amazing, truly brilliant @clairelepichon.bsky.social who just received TENURE from our NIH intramural program.
- Reposted by Alex Chesler
- Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel. buff.ly/ypISrtx
- Another write up of the work led by @dimacd.bsky.social. We debated a long time whether and how to report his largely negative results.
- And a teaser… stay tuned. This work is the appetizer to his major work, which we hope to wrap up soon.
- Reposted by Alex CheslerTurns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel. buff.ly/ypISrtx
