Alberto Macho
Scientist studying Plant-Pathogen Interactions (Molecular Biology - Biochemistry - Genetics). Scuba diving. Hiking. Football. Photography
- Our latest paper is now online at New Phytologist! Phosphorylation-dependent association of a bacterial effector with plant 14-3-3 proteins enhances effector stability and bacterial virulence doi.org/10.1111/nph.... @newphyt.bsky.social
- RipBM is an unconventional type-III effector from Ralstonia, in the sense that it encodes a kinase domain, although, in our experience, kinase activity is not detectable. Sustained RipBM expression in eukaryotic cells leads to cell death, which seems to be a toxic effect of RipBM activity
- However, RipBM is phosphorylated by SnRK-family proteins in plant cells and subsequently associates with plant 14-3-3 proteins, which prevent RipBM ubiquitination and degradation
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View full threadTogether with our previous report earlier this year (Yu et al, PLoS Pathogens, 2025), this work suggests that hijacking plant kinases is an important strategy for bacterial effectors to promote their own phosphorylation and stability in plant cells doi.org/10.1371/jour...
- Reposted by Alberto MachoOur new paper is out in New Phytologist! We describe how the Ralstonia solanacearum effector RipAV suppresses plant immunity by directly interfering with key defense regulators. 🧵👇 nph.onlinelibrary.wiley.com/doi/10.1111/...
- Our latest article is now online! @PlantBiotechnologyJournal Expression of Arabidopsis FLS2 in N. benthamiana confers responsiveness to Ralstonia flg22 and activation of anti-bacterial immunity doi.org/10.1111/pbi.... By Meng Li, Yujiao Chen, and Yali Wei
- Before, we identified 2 residues in soybean FLS2 that contribute to the gain of recognition of the polymorphic Ralstonia flg22 (see attached paper) doi.org/10.1038/s414... Then we tried to see if mutating the equivalent residues in Arabidopsis FLS2 would confer recognition
- We did not see any gain of flg22Rso-triggered ROS burst, but… there was MAPK activation. Surprisingly, what was supposed to be a “negative control”, even WT AtFLS2 expressed in N. benthamiana would confer MAPK activation upon flg22Rso treatment
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View full threadHopefully, the information that heterologous PRR expression can confer novel PAMP recognition could provide new information for the design of synthetic immune receptors with expanded recognition of polymorphic pathogen elicitors
- Reposted by Alberto MachoAbsolutely gorgeous images showing expression reporters in Pseudomonas syringae from @type3lab.bsky.social - variety in flagella and type iii secretion system expression within a group of cells. #2025ISMPMI
- Reposted by Alberto MachoPlease don't miss it! A great session on the spatial and temporal regulation of plant–microbe interactions, hosted by @uprogress.bsky.social and @tatsuyanobori.bsky.social Many attractive talks, including our latest research presented by @crbeuzon.bsky.social #ISMPMI2025 #MicroSky #PlantScience
- TODAY. 15:15 @ Room P&Q #2025ISMPMI
- Reposted by Alberto MachoCajal bodies are membraneless structures with fundamental roles across eukaryotes—but which proteins actually make them up? Using FAPS, Zhou et al. isolated 34 million plant Cajal bodies and profiled their proteome via LC-MS/MS. Curious? Check out our latest preprint! www.biorxiv.org/content/10.1...
- Reposted by Alberto MachoIt's Friday and it's #NationalMojitoDay! Here's some of the chemistry behind this refreshing minty cocktail 🍹 www.compoundchem.com/2020/07/10/m... #ChemSky 🧪
- Reposted by Alberto MachoIt was such a pleasure to host @albertopmacho.bsky.social at the @zmbp-tuebingen.bsky.social —in his little detour on his way to Cologne for the #2025ISMPMI. “Deciphering the interaction between plants and bacterial pathogens: beyond activation and suppression of immunity”—what a treat we got!
- Happy and proud to participate in this collaboration between my home countries 🇪🇸🇨🇳
- 📜 El #CSIC firma dos memorándums de entendimiento con la Academia China de Ciencias 🏛️ Ambas instituciones promoverán la cooperación científica centrada en proyectos sobre agricultura sostenible, alimentación y cambio climático 👉 tiny.cc/s5km001
