Matthew Aguirre
Incoming postdoc at Genentech | PhD from Stanford Biomedical Data Science.
- Thrilled to share the second half of my PhD work here! We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/) doi.org/10.1101/2025...
- Expression QTLs are a nice way to map genetic effects onto genes (e.g., SNP → E → Trait). But a lot of expression variance (~70% of h2) is spread across the genome, ergo hard to discover statistically. Data from pubmed.ncbi.nlm.nih.gov/31558840/ (2/)
