- New Preprint! 🚨 Most AMR data gets collapsed into “resistant” vs “susceptible.” But resistance isn’t a simple switch — it changes gradually, and often in correlated ways across drugs.
- By ignoring that structure, we lose the early warning signs of resistance emerging — and miss how resistance evolves in real populations.
- In our new preprint we introduce AMR Cartography: a way to map full resistance profiles into simple 2D maps.
- Instead of treating correlations between drugs as noise, we use them as insight. That lets us see: • subtle shifts before breakpoints • co-resistance patterns • collateral sensitivity trade-offs • identify genetic markers for resistance
- Applied to 3,600+ pneumococcal isolates, AMR Cartography revealed lineage-specific resistance and the genetic changes driving multidrug resistance.
- The framework works across species & drug classes — and the code is open-source. Would love to hear feedback from those working in AMR surveillance! Preprint: www.biorxiv.org/content/10.1...
Sep 30, 2025 08:48