- Our work on the Panoptes antiphage system is published! Here we find that Panoptes "watches" the cytosol for phage immune evasion proteins–captured in this illustration by Clair Huffine of Insight Illustrations. A beautiful example of the effector triggered immunity paradigm.
- Nucleotide second messengers are frequently antagonized by viruses. However, Panoptes turns this weakness into an opportunity. www.nature.com/articles/s41...
- Panoptes guards the CBASS pathway (bacterial cGAS-STING). One facet of this work that I find particularly exciting is the genetic linkage between Panoptes and CBASS, which significantly co-occur in bacterial genomes. What other phage defense systems may be genetically (and functionally) linked?Oct 8, 2025 11:14
- This work was led by @aesully98.bsky.social and was a fantastic collaboration with @benmorehouse.bsky.social + lab. Thanks to all authors including Aravind and Max Burroughs at NIH
- Check out the complementary story from @doudna-lab.bsky.social led by @erinedoherty.bsky.social and @benadler.bsky.social Their work on OptE oligomerization is particularly crucial to completing our understanding of Panoptes. www.nature.com/articles/s41...
- @mfwhite2.bsky.social reviewed both papers in a News and Views and put the collaboration between phage defense systems best: "scientists can confidently conclude that bacterial defences are indeed more than just the sum of their parts" www.nature.com/articles/d41...
