Guido Meijer
👨🔬 Neuroscientist at the Donders Institute in the Battaglia lab.
🧠 Previously: International Brain Laboratory
Using Neuropixels and virtual-reality to understand how the brain creates internal models of the world.
www.guidomeijer.com
- Reposted by Guido MeijerMain postdoc study out! We can redefine prefrontal cortex regions with single-unit activity! Grateful to @carlenlab.bsky.social and @weltgeischt.bsky.social who made this crazy project real. Thanks to all co-authors, collaborators, and reviewers. www.nature.com/articles/s41...
- Reposted by Guido MeijerfMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:
- The Power Pixels pipeline just keeps getting better! The latest update comes with: - OpenEphys support - AP_Histology support - automatic high-frequency noise reduction - NWB format export option - zarr compression of raw data And, most importantly: a cool new logo! github.com/NeuroNetMem/...
- Halloween isn’t my thing. My idea of a scary night is reading the plots of horror movies on Wikipedia.
- I never understood why everyone always complains about the clocks changing. Then I had a kid.
- Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵
- Journals have criteria figures have to adhere to. Generally, a full-width figure should be 7 inch wide and font sizes cannot be smaller than 7 pts. If you get into the habit of always creating figures that fit these criteria this will save you a lot of time when submitting.
- The font size of each plot element can be easily set with seaborn. Write a function like this that sets the font size and any other style element you like to have in all your plots and the function each time before plotting (link to the code in the last post).
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View full threadI hope you found this useful! Here is a Google Colab with example code of what was discussed in this thread: colab.research.google.com/drive/1UlCET...
- I was doing the second-to-last recording of my project and was happily thinking to myself that I haven't broken a single Neuropixel in the entire two year project. You can guess what happened next... Now I have to install a new probe just for one final recording 🙃
- I love how they came up with all this random stuff but for this one area they were like "I really don't know, just put a question mark"
- When I told my dad I published in Nature he was like "wow, you must have made a lot of money with that"
- I don't know why people say X is going down the drain, my last post got lovely replies like this one:
- Reposted by Guido MeijerWant to collaborate with the International Brain Laboratory on your own project? We have funding to work with groups anywhere in the world to do new large-scale projects and we are looking for new partners! Learn more and apply: www.internationalbrainlab.com/ibl-core-apply
- Reposted by Guido MeijerThrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
- Reposted by Guido MeijerIf you're into podcasts, here's a good one on the @intlbrainlab.bsky.social brainwide map, by @newscientist.com www.newscientist.com/podcasts/fir...
- Reposted by Guido MeijerSad day for peope who still believe brain areas are the primary organizational units of function in the brain. www.nature.com/articles/s41...
- Reposted by Guido MeijerThe @intlbrainlab.bsky.social published 2 papers today on their work to create a map of neural activity across the entire mouse brain. Learn more about the lab: simonsfoundation.org/2025/02/20/how-do-o…
- Reposted by Guido MeijerThe first complete activity map of a mammalian brain has revealed unprecedented insights into how decisions are made – and may even hint at the roots of intuition.
- Extremely proud to have contributed to this monumental effort of recording the entire mouse brain, at cellular resolution, during complex behavior 🧠🐭
- Two flagship papers from the International Brain Laboratory, now out in @Nature.com: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +
- PSA: don't buy duragel from Cambridge Neurotech, it's a scam! 🚨 They charge $200 (incl. shipping) for a 16 ml spout. But duragel is just DOWSIL 3-4680 (see paper below) of which you can buy a large container of 210 ml for only $110. That's 24 times cheaper! 💸 www.sciencedirect.com/science/arti...
- Duct tape and hope are literally the only two things holding my rig together
- 🚨 NEW #FoSci post. "You don't build a mission on duct tape and hope." Our VP of #ResearchIntegrity, Dr Leslie McIntosh @mcintold.bsky.social, reflects on almost a year of Forensic Scientometrics and its discussion of trust in science & research. 🔗 Read now: fosci.substack.com/p/beyond-duc...
- Don't feel like reading? Check out my talk! www.youtube.com/watch?v=QIl6...
- 🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...
- 🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...
- These are all the Neuropixel insertions we made across the mouse brain while optogenetically stimulating serotonergic neurons in the dorsal raphe nucleus with a fiber (thick grey tube). We recorded ~7500 neurons in total across a large number of brain regions 🧠 (2/9)
- We found widespread modulation of neural dynamics across all recorded brain regions. Single neurons were either excited or inhibited by 5-HT. Regions like the PAG, mPFC and OFC were excited by serotonin whereas the hippocampus was suppressed. Regions in the middle were more balanced. (3/9)
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View full threadThis project is part of the @intlbrainlab.bsky.social, funded by @simonsfoundation.org and @wellcometrust.bsky.social. Big thanks to my PI Zachary Mainen (not on Bluesky) at the @champalimaudf.bsky.social, Lisbon, Portugal ☀️ (9/9)
- Was watching Clarkson's Farm and kept wondering how AI was going to help them get calves only to realize it stands for artificial insemination
- Just added Bombcell 💣 to the suite of automatic curation tools that's included in the Power Pixels pipeline! It runs Bombcell, UnitRefine and the IBL algorithm to classify which of your units are good single neurons. You can can then use one (or more!) of these to filter your units before analysis.
- Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv! www.biorxiv.org/content/10.1...
- Reposted by Guido Meijer🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds. pip install and play around with our toy dataset: 🔗 github.com/Julie-Fabre/...
- Do you do Neuropixel recordings and are you struggling with preprocessing? The Power Pixels pipeline is an easy-to-use pipeline from raw data to neural activity of single neurons in specified brain regions 🧠 Now on bioRxiv! www.biorxiv.org/content/10.1...
- My daughter can now understand two words! When I say "clap" she claps her hands and when I say "shake" she shakes her head. Ten months of development and she's reached the level of intelligence of a dog.
- Reposted by Guido MeijerOfficially announcing my new game: GARBAGE COUNTRY. A lonely road trip through the ruins of a forgotten world. feat. vast wastelands, tower-defense battles, upgrades, mysteries, & lots of driving.
- Reposted by Guido MeijerOh wow. Starting grant 0-10 years post PhD from 2027, Consolidator 5-15
- Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv
- Reposted by Guido Meijer🚀 Datoviz v0.3 is out! High-performance GPU rendering for scientific data visualization, now with a Pythonic API, 2D axes, and improved docs & gallery. 🔗 datoviz.org 🐍 pip install datoviz #dataviz #vulkan #python #gpu #opensource #neuro #sciViz
- I don't want to brag but my 9 month old baby already speaks two languages. She can say yes in Russian ("da") and grandfather in Hindi ("dada").
- On my way to New York for the @intlbrainlab.bsky.social annual meeting! Luckily, as a new father, the concept of jetlag doesn't apply to me anymore.
- Reposted by Guido MeijerThe lab's latest published project lead by our recently graduated Dr. Rhiannon Robke! --> Optogenetic stimulation of novel TPH2-Cre rats advances insight into serotonin’s role in locomotion, reinforcement, and compulsivity (www.jneurosci.org/content/earl...).
- Reposted by Guido MeijerMy lab @kinshiplab.bsky.social is recruiting a postdoc 🚨 with Sept start date Preference for in-vivo ephys / circuits experience / interest in applying quantitative methods to natural social behaviour. Funding & visa fees for 1-yr with possible extension. Send me your CV & visit kinshiplab.org
- My theory is that our universe, and everything in it, is a computer simulation made by a highschool student of some advanced civilization. Not even a particularly bright one. He hard coded that nothing can go faster than the speed of light just because it would make the math more complicated. (1/2)
- Also, his laptop probably didn't have enough power to compute the position of every electron all the time so he just coded them as probability distributions. That's why we have quantum mechanics. He probably got a C- for it. #showerthoughts (2/2)
- Only now I have a baby do I realize it's pretty crazy we have predators with sharp claws and teeth just chilling in our homes.
- The PhD students started writing motivational quotes on the whiteboard
