Meg T (she/her/hers)
Bio x ML @ Romero lab, @dukeubme.bsky.social
@ml4proteins.bsky.social co-organizer
- Reposted by Meg T (she/her/hers)Horrifying news being confirmed about the state of NSF at the NSF IOS/BIO webinar
- Reposted by Meg T (she/her/hers)A dataset of 40 million protein families and an autoregressive model of protein families. Great to see other protein Atlases popping up after Dayhoff!! @judewells.bsky.social @dmmiller597.bsky.social www.biorxiv.org/content/10.6...
- Excited to be at the Carolina Biophysics Symposium the next two days to hear and talk about protein eng and design in many therapeutic and green science spaces!! Special thanks to our friends at @unc-bcbp.bsky.social for organizing! Gonna be an exciting time! cbs.web.unc.edu
- Reposted by Meg T (she/her/hers)Design stable, folded proteins using only the 10 "ancient" amino acids. www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)Three BioML starter packs now! Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc Pack 3: go.bsky.app/NAKYUok DM if you want to be included (or nominate people who should be!)at://did:plc:vcfu4zw4mstjnpvqb7yqby32/app.bsky.graph.starterpack/3lapi2tgwmz2y
- Reposted by Meg T (she/her/hers)Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment. The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP jasonjwilliamsny.github.io/grfp2025/
- Reposted by Meg T (she/her/hers)I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social pubs.acs.org/doi/10.1021/...
- Reposted by Meg T (she/her/hers)The posting is unfortunately not super clear on this, but please apply if you want to do BioML research, especially around machine learning for molecular biology and bioengineering! I get sad if there are no applicants with this profile in the pool!
- Reposted by Meg T (she/her/hers)Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!
- Partially-latent flow matching enables sequence-structure codesign of large proteins and functional motif scaffolding. @kdidi.bsky.social @machine.learning.bio @karstenkreis.bsky.social @arashv.bsky.social arxiv.org/html/2507.09...
- Reposted by Meg T (she/her/hers)Really nice metastudy of citizen science contributing to ecology & biodiversity research @inaturalist.bsky.social @aibsbiology.bsky.social 👀🔎🍄🧪🌎🌐 iNaturalist accelerates biodiversity research academic.oup.com/bioscience/a...
- Reposted by Meg T (she/her/hers)The MLSB workshop will be in San Diego, CA (co-located with NeurIPS) this year for its 6th edition in December 🧬🔬 Stay tuned @workshopmlsb.bsky.social as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
- Reposted by Meg T (she/her/hers)There's a lot more in the preprint! www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known. Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.
- “Writing compels us to think — not in the chaotic, non-linear way our minds typically wander, but in a structured, intentional manner. By writing it down, we can sort years of research, data and analysis into an actual story, thereby identifying our main message and the influence of our work.”
- Reposted by Meg T (she/her/hers)🧪 The EPA is eliminating its scientific research arm and firing hundreds of scientists. This move, enabled by a Supreme Court ruling, dismantles the office providing independent research for environmental policies. #Climate
- Reposted by Meg T (she/her/hers)We're sponsoring the use of ESM3 and EMSC to help researchers engineer improved PETase enzymes in the @AlignBio 2025 Protein Engineering Tournament. Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...
- 1/4 🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️ #AIforBiology #ClimateTech #ProteinEngineering #OpenScience
- Reposted by Meg T (she/her/hers)1/4 🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️ #AIforBiology #ClimateTech #ProteinEngineering #OpenScience
- Reposted by Meg T (she/her/hers)Unfortunately, the MLSB Workshop @ NeurIPS (@workshopmlsb.bsky.social) was rejected this year. Feedback from the deciding committee indicates it was a coin flip decision, with 283 proposals & a number related to “computational biology” More on the future of MLSB soon…
- Pls tell me im living under a rock and we have citation managers compatible with iPads where your writing & highlighting can be automatically transcribed into notes and key words attached to a pdf (vs me manually transcribing over from edits I make in Adobe??) In the age of AI, we have this, right??
- Reposted by Meg T (she/her/hers)With contributions from fantastic colleagues @martinsteinegger.bsky.social , @mikeinouye.bsky.social, @jlistgarten.bsky.social , @ideasbyjin.bsky.social, @michael-heinzinger.bsky.social, and many more, the first CSHL volume on ML for Protein Science and Engineering is out: lnkd.in/dQdgGPpp
- Reposted by Meg T (she/her/hers)Physics-based design of efficient Kemp eliminases @lynnkamerlin.bsky.social www.nature.com/articles/s41...
- Reposted by Meg T (she/her/hers)All all-atom diffusion model of protein sequences. www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)End-to-end differentiable homology search for protein fitness prediction. @yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social arxiv.org/abs/2506.089...
- Reposted by Meg T (she/her/hers)🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction. 🧵 1/9
- Reposted by Meg T (she/her/hers)Which RNAs are functional? Been a long time goal of @deboramarks.bsky.social to start an RNA sequence —> function and structure mapping. Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
- Reposted by Meg T (she/her/hers)RNA, RNA, RNA -> RNAGym! read all about it! biorxiv.org/content/10.110… Been a long time goal of @deboramarks.bsky.social We tried a million years ago, sciencedirect.com/science/articl��� Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
- Reposted by Meg T (she/her/hers)Happy to release our breakthrough AI-model: RareFold, which predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, wet lab validated. 📄 biorxiv.org/content/10.1... 💻 github.com/patrickbryan...
- Reposted by Meg T (she/her/hers)🎉 Congrats to Nate for his awesome preprint! We used deep learning to design phages with complex infectivity and specificity profiles. Big shifts in host targeting come from just a few mutations! Training on multifunctional data enables precise control over protein properties 🧬 tinyurl.com/yc4wtn8h
- Reposted by Meg T (she/her/hers)Super excited to be presenting Dyna-1 next week with @hkws.bsky.social !!
- Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!
- Happening in 15 mins! Message if you need a link :)
- Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!
- Reposted by Meg T (she/her/hers)Indeed, 1 A.A. mutation from each of these hotspots dramatically extended the pulsatory response (>18 hrs vs 10s of min), suggesting evolutionary tuning of dynamics.
- Reposted by Meg T (she/her/hers)Remarkably, sequence analysis found these *exact same hotspots* had co-evolved in BcLOV4 homologs, implying function.
- Reposted by Meg T (she/her/hers)Structural studies (limited proteolysis, HDX-MS by the Gardner lab) identified temperature-sensitive hot-spots in DUF.
- Reposted by Meg T (she/her/hers)What about the temperature-sensitive inhibitory Node C? We mapped this to the mysterious “Domain of Unknown Function” (DUF). We still call it DUF even though function is now known :P.
- Reposted by Meg T (she/her/hers)We then mapped the network nodes: The light-sensing LOV domain (A) regulates a charged clustering region (B), which drives PM binding. Aside: this inspired an entire toolset for single-protein translocation to various compartments. Preprint soon!
- Reposted by Meg T (she/her/hers)The inter-domain IFFL idea started as a hunch, but models made several non-intuitive predictions that we then confirmed experimentally through mutations that altered the energetics of LOV domain interactions.
- Reposted by Meg T (she/her/hers)Answer: smaller-scale networks of interactions between the protein’s domains. Light response (A) quickly activates a region for plasma membrane (PM) binding (B), but also enables a temp.-sensitive domain (C) to inhibit the PM-binding region more slowly.
- Reposted by Meg T (she/her/hers)Step-to-pulse response – adaptation – is common in all kinds of networks, often through an incoherent feed-forward loop (IFFL). Node A quickly activates Node B but also —more slowly— Node C, which inhibits Node B. Result: a pulse of B. But how can a single protein do it w/o a larger network?
- Reposted by Meg T (she/her/hers)Why does BcLOV4 turn itself off despite constant light stimulation, and why does this depend on temperature? The answer could make better optogenetic and thermogenetic tools, and itself was a fascinating puzzle.
- Reposted by Meg T (she/her/hers)How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵
- Reposted by Meg T (she/her/hers)Search among all posts in this feed 👉 mlsb.papers.blue
- Reposted by Meg T (she/her/hers)Structure models generate proteins with higher structure confidence and more plausible energy distributions, but limited diversity and sequence biases. Sequence models generate diverse and novel proteins with lower structural confidence. Neither are good at generating enzymes.
- Reposted by Meg T (she/her/hers)RFDiffusion2: a diffusion model that scaffolds enzyme active sites at the atomic level enables the generation of functional de novo enzymes www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)Congratulations to Elliott Weix on being named a 2025 Goldwater Scholar! Weix, a biochemistry and math major, works in the @cellraiser.bsky.social Lab. biochem.wisc.edu/2025/04/10/b...
- Reposted by Meg T (she/her/hers)Supervised training using data generated by multiplexed assays of variant effects is potentially very powerful, but is made difficult by assay- and protein-specific effects Here @tkschulze.bsky.social devised a strategy to take this into account while training models www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)Our work on better ways of aggregating PLM embeddings is now out in Bioinformatics Advances.
- 🧬 Now in Bioinformatics Advances: "Aggregating residue-level protein language model embeddings with optimal transport" Explore the full paper: doi.org/10.1093/bioadv/vbaf060 #ProteinRepresentation #MachineLearning #Bioinformatics @rohitsingh8080.bsky.social
- I haven’t hosted in quite some time!! But super excited to be back today and host Anthony as he goes over his new paper out in Nature! Note the 11AM EST time change (so he isn’t up too late on the other side of the globe😉) hope to see people there!
- Next Tues (4/1) at **11AM** ET we will have Anthony Marchand present "Targeting protein–ligand neosurfaces with a generalizable deep learning tool" Paper: www.nature.com/articles/s41... Sign up on our website for zoom links!
- Reposted by Meg T (she/her/hers)Now just a few days left to submit your abstract for a chance to join this fantastic protein design meeting 📅 📜 🧬 💻
- ⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️ Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨🔬👩🔬👩💻👨💻 Submit your application via: benzon-foundation.dk/benzon-sympo...
- Reposted by Meg T (she/her/hers)Gene synthesis is often the most expensive part of protein engineering with generative models. Happy to have played a small part in this work, where Chase developed a method for precision library construction at scale, with per-gene costs as low as $1.50. @philromero.bsky.social
- 🎉Congrats to Chase on her new preprint! She developed OMEGA--a simple method for assembling custom gene panels for as little as $1.50 per gene. Big step forward protein engineering and design!🧬 www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)We collaborated with @hf.co 🤗 to host all of our models and data online! Big thank you to @danielvanstrien.bsky.social @wauplin.hf.co @lhoestq.hf.co for helping out (and the GPU)! Dyna-1 and RelaxDB on HF: 🚀 huggingface.co/spaces/gelne... 🌟 huggingface.co/datasets/gel...
- Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics? @hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1! 🧵
- Reposted by Meg T (she/her/hers)🎉Congrats to Chase on her new preprint! She developed OMEGA--a simple method for assembling custom gene panels for as little as $1.50 per gene. Big step forward protein engineering and design!🧬 www.biorxiv.org/content/10.1...
- Reposted by Meg T (she/her/hers)Scalable and cost-efficient custom gene library assembly from oligopools biorxiv.org/content/10.1101/202…
- From a colleague in my PhD lab! Chase presents her method OMEGA, a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! #synbio #proteinengineering #OMEGA
- Scalable and cost-efficient custom gene library assembly from oligopools biorxiv.org/content/10.1101/202…
- Reposted by Meg T (she/her/hers)Here's my interview with @stevenstrogatz.com on @quantamagazine.bsky.social's Joy of Why podcast. This was *so much fun*. I was nervous going into it (I really look up to Steve!), but I had a blast and I think this is the best interview I have ever done. Thanks for having me on, folks!
- In the history of evolution, multicellularity has evolved independently at least 50 times. But we’ve only figured that out in the past few decades. Listen to the first episode of the new season of “The Joy of Why” with hosts @stevenstrogatz.com and Janna Levin. www.quantamagazine.org/how-did-mult...
- Reposted by Meg T (she/her/hers)Next Tues (3/18) at 4PM ET we will have Alan Amin present "Bayesian Optimization of Antibodies Informed by a Generative Model of Evolving Sequences" Paper: arxiv.org/abs/2412.07763 Sign up on our website for zoom links!
- Today’s the day! And still time for you to find one near you!! standupforscience2025.org
- Reposted by Meg T (she/her/hers)“the success of the American research establishment is extraordinary … this is based on a deal where the government provides funding & in exchange it gets products, research, national security, prestige & the next generation of qualified scientists” 🧪 #AcademicSky www.princeton.edu/news/2025/02...
