Gilles FISCHER
Evolution, Genomics, Yeast
- Reposted by Gilles FISCHER#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz
- Reposted by Gilles FISCHERCheck out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
- Reposted by Gilles FISCHERExcited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬 www.sciencedirect.com/science/arti...
- Reposted by Gilles FISCHERRegistration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social
- Reposted by Gilles FISCHERThe deadline for the submission of papers to the special issue on the International Yeast Meetings of 2025 has been extended to 31 March. Papers should be connected to one of the meetings listed below. Hurry up and don't miss this chance! More information at: onlinelibrary.wiley.com/page/journal...
- We are very happy to announce that #Yeast is launching a new special issue on the International Yeast Meetings of 2025: #ICYGMB32, #pombe2025 and #ISSY38. The deadline for abstract submission is 30th September 2025. Hurry up!!! More info in the thread below. onlinelibrary.wiley.com/page/journal...
- Reposted by Gilles FISCHEREMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond. We extend our deepest condolences to his family, friends, and colleagues. www.embl.org/news/people-...
- Reposted by Gilles FISCHERSad to hear that Oxford Nanopore wants to discontinue the P2Solo later this year in favor of the P2i (the very pricey P2Solo that comes with a GPU to do the basecalling in it) It feels like such a big step in the wrong direction. They are a great sequencing company, not a great GPU upseller...
- Reposted by Gilles FISCHER📣 #paper "Uncovering actionable trade-offs of antifungal resistance in a yeast pathogen" Check out our new publication in @molsystbiol.org where we systematically map stress-related trade-off associated with drug resistance in Candida glabrata (N. glabratus) link.springer.com/article/10.1...
- Last paper in collaboration with Zhou XU. We explored the natural telomere length diversity in S. cerevisiae and found that ploidy level, and subtelomere structure drive telomere length variation. Higher ploidy levels lead to telomere elongation! genome.cshlp.org/content/earl...
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- Reposted by Gilles FISCHERFresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41... Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
- Reposted by Gilles FISCHERHappy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!
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- Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...
- Our work is published back to back with a complementary study led by Jing Hou in @schacherer.bsky.social lab www.pnas.org/doi/10.1073/...
- Great paper on the genetics of facultative multicellularity in marine yeast www.nature.com/articles/s41...
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- Reposted by Gilles FISCHERHere is our first publication of 2026 which is the first article of a special issue that mark the journal 40 anniversary - happy new year to all the #yeast community
- In this #Yeast review article, Jens Nielsen discusses how Saccharomyces cerevisiae has been used as both a model organism and a cell factory, shedding light on the molecular mechanisms of eukaryotic life but also boosting industrial biotechnology 💪💪💪 onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Gilles FISCHERThe new year has just started and we are happy to share the news that the new issue of #Yeast (Volume 42, Number 12, December 2025) is finally out!!! 😀😀😀 This issue includes two research articles and two reviews. You can browse it at this link: onlinelibrary.wiley.com/toc/10970061...
- Reposted by Gilles FISCHERExtinction rarely departs with drama, it slips out the back door while we’re still debating the guest list. These records are made official on the Red List. "Conservation failures are often recognised only once they can no longer be reversed." via @mongabay.com: news.mongabay.com/short-articl...
- Reposted by Gilles FISCHERAs many of us 🎁 things up for the year, make sure all your ℹ️'s are dotted- and all your #yeast emojis are downloaded! If you haven't yet, make sure to add the emojyeast collection to all your 📱💻🖥️⌚️ mayaschuldiner.wixsite.com/schuldinerla... Thanks to the amazing Schuldiner lab for these!
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- Reposted by Gilles FISCHERWhen colonizing a new habitat, organisms adapt to maximize their reproductive success via #LifeHistory #evolution. @ecoevodevolab.bsky.social @cbank.bsky.social show that life history evolution facilitates niche diversification across a range of theoretical models @plosbiology.org 🧪 plos.io/4p7YT0a
- Reposted by Gilles FISCHERIn the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway. onlinelibrary.wiley.com/doi/10.1002/...
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- Reposted by Gilles FISCHERIndependently evolved supergenes control colony social organization and queen reproductive strategies in several ant lineages. Sigeman et al. uncover a novel 9 Mb supergene controlling queen size and social organization in Myrmica ruginodis. 🔗 doi.org/10.1093/molbev/msaf255 #evobio #molbio #ants
- Reposted by Gilles FISCHERThe new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃 You can browse it at this link: onlinelibrary.wiley.com/toc/10970061...
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- Reposted by Gilles FISCHERBig congratulations to Dilanaz Arisan (@rquatrini.bsky.social 's lab) and Pablo Quintrel (@fcocubillosr.bsky.social 's lab) for winning the best posters awards sponsored by the #Yeast journal at the @smbe-chile2025.bsky.social conference in Puerto Varas 🎉🎉🎉
- Reposted by Gilles FISCHERThe special issue will be guest-edited by @pjboynton.bsky.social (Wheaton College Massachusetts, USA) and Pei-Yun Jenny Wu (CNRS Bordeaux, France). You can find more information on the accepted topics and submission instructions by using the QR code below:
- Reposted by Gilles FISCHERNew #Yeast paper out from the series #FantasticYeasts!!! @hittingerlab.bsky.social , Dana Opulente & team describe a novel species, Lachancea rosae, isolated from the wild rose Rosa californica 🌹 onlinelibrary.wiley.com/doi/10.1002/...
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- New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity www.biorxiv.org/content/10.1...
- Reposted by Gilles FISCHERUtterly devastating: FlyBase zapped. www.thetransmitter.org/community/ha... #modelOrganism
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- Reposted by Gilles FISCHER"Fungi can see and react to a wide range of colors." journals.asm.org/doi/abs/10.1...
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- Reposted by Gilles FISCHERStunning! An 8-hour time-lapse to show the Earth is rotating while capturing the Milky Way.
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- Reposted by Gilles FISCHERIt’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...
- 🎉 The final Yeast 2025 conference program is now live! Check out the full list of oral presentations and posters. We can't wait to share the science (and more 🍷) with you! 🔗 premc.org/yeast2025/ 🔗 yeast2025.exordo.com/programme/at... #Yeast2025
- 📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....
- Reposted by Gilles FISCHERNIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
- 🚨 We're hiring! 🚨 A 2-year postdoc position is now open in our lab to explore the fascinating world of yeast polyploid genomes, their structure, stability, and adaptive potential. 🔗 More info here: docs.google.com/document/d/1... Please repost! #Postdoc #Genomics #Yeast #Polyploidy #Evolution
- Reposted by Gilles FISCHERRibosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay
- Wow, super impressive biomedical innovation! “Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases | Pritzker School of Molecular Engineering | The University of Chicago pme.uchicago.edu/news/inverse...
- Reposted by Gilles FISCHERIn the latest research article of the series #technoYeast, Han-Ying Jhuang, Dimitra Aggeli & Gregory Lang estimate the efficiency of transformation vs cytoduction in introducing plasmids into #yeast, and show that cytoduction is significantly more efficient. onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Gilles FISCHERWe are delighted to introduce @melaniadangiolo.bsky.social as a new member of our editorial board. Melania will be in charge of Communications & Engagement for the #Yeast journal. Welcome aboard!!! 😀 onlinelibrary.wiley.com/page/journal...
- Reposted by Gilles FISCHERThis special issue is guest-edited by Carla Gonçalves (Universidade NOVA de Lisboa, Portugal), @ishengtsai.bsky.social (Academia Sinica, Taiwan), @khowell.bsky.social (University of Melbourne, Australia) & Florian Bauer (University of Stellenbosch, South Africa)
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- The #Yeast2025 conference is now FULL with around 500 attendees! 🎉 - Thank you to everyone who registered. We’re excited to introduce new sessions: 🧠 ERC Grant Career Paths @erc.europa.eu 🤝 Meet the Industry 📝 Meet the Editors We can’t wait to welcome you! premc.org/yeast2025/
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- Reposted by Gilles FISCHERSorbonne Université apporte son soutien au projet Hypatie, visant à faire inscrire les noms de 40 femmes scientifiques sur la Tour Eiffel ! 🙌 💪 Une initiative importante pour rendre aux femmes la place qui est la leur dans notre mémoire et notre histoire scientifique #WomenInScience
- 32nd International Conference on Yeast Genetics and Molecular Biology - Paris - July 21-24, 2025 📢 With nearly 400 abstracts submitted, the #Yeast2025 conference promises to be rich and exciting! Can't wait to see the latest in yeast research premc.org/yeast2025/
- A new tool for ploidy estimation that will be useful for the #yeast and #plant communities and beyond bmcgenomics.biomedcentral.com/articles/10....
- International Conference on Yeast Genetics & Molecular Biology - #Yeast2025 🥖🍺 🍷🍶 🌳🦟 🧬 Last week to submit your abstract: premc.org/yeast2025/su...
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- The Lord of the Yeasts!
- Just add sorbitol! onlinelibrary.wiley.com/doi/full/10....
- Reposted by Gilles FISCHER1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...
