Simon A. Sharples, PhD 🇨🇦
Research Fellow studying motor systems neuroscience in Cincinnati
- I'm particularly proud to have one of my images selected and featured on the cover of the latest issue of @jphysiol.bsky.social In this issue, you can also read about my latest work on gamma motoneurons! Check it out!! physoc.onlinelibrary.wiley.com/doi/10.1113/...
- Our latest issue is now live🎉 Featuring cover art from Sharples et al. (2025) depicting a motoneuron from the lumbar spinal cord of a newborn mouse📷🔬 🔗 Read the full issue here: physoc.onlinelibrary.wiley.com/toc/14697793...
- Check out our recent publication from my postdoc in @uniofstandrews.bsky.social in the Miles Lab published in @cp-cellreports.bsky.social that describes a cholinergic spinal circuit that is vital for fine-tuning motor output during breathing. www.sciencedirect.com/science/arti...
- Want to learn more about gamma motoneurons? Check out our recent preprint from my postdoctoral work in the Miles Lab @uniofstandrews.bsky.social providing insight into how these cells are tuned to support motor function. www.biorxiv.org/content/10.1...
- Reposted by Simon A. Sharples, PhD 🇨🇦Congratulations & welcome to Dr Simon Sharples from cincychildrens.bsky.social who joins us as one of our 2025 Editorial Board Fellows! 🎓 🎉
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- 🚨 New Research Alert! 🚨 Thrilled to share my final PhD paper—also my first as corresponding author, recently published in @iScience! We investigated spinal circuits that contribute to episodic locomotor activity. www.sciencedirect.com/science/arti...
- Locomotor CPGs are known for generating rhythm and pattern, but locomotor behaviors are often episodic. The circuits behind this remain poorly understood.
- By studying dopamine-elicited episodic rhythmic activity in isolated spinal cords of newborn mice, we found that episode-generating circuits arise from ventral horn interneurons across thoracic, lumbar, and sacral segments.
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View full threadHuge thanks to the co-authors from the Whelan and Miles Labs that made this all possible!
- We've always wondered what V0g's were up to. Now we're a big step closer to knowing! Nice to see this great work out!
- 🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think: www.biorxiv.org/content/10.1...
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