Jeremy Garb
PhD student at the Sorek lab.
Immune proteins.
- 📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...
- Some background 📖 Bacteria are far from defenseless. They carry dozens of anti-phage and anti-plasmid systems—CRISPR is just the tip of the iceberg. ➡️ This makes phage therapy often fail in patients. ➡️ It also makes many bacteria very hard to genetically engineer.
- What if we design proteins to disable these defenses? Using AI-driven de novo protein design (RFdiffusion), we created small proteins (49–98 aa) that bind and block bacterial defense proteins 💻🤖🧬
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View full threadI had so much fun making this project come to life! Huge thanks to everyone who made it happen 💙 - especially my brilliant collaborators David W. Adams, Eliane Hadas Yardeni, @mblokesch.bsky.social, and of course @soreklab.bsky.social
- @dinahoch.bsky.social dingazzz
