Nature Cardiovascular Research
Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology.
nature.com/natcardiovascres/
- Research | Da Pra et al. show physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their regenerative effects. www.nature.com/articles/s44... rdcu.be/e2Fa9
- 21/01/2026 ❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more. www.nature.com/natcardiovas...
- Research | Kathiriya et al identify a cardiac Tbx5+/Mef2cAHF+progenitor lineage that bisects the intraventricular septum during the development and show that alterations in this lineage lead to congenital heart disease. www.nature.com/articles/s44... rdcu.be/eZGiu
- Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event! www.youtube.com/watch?v=4wmn...
- ❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more. www.nature.com/natcardiovas...
- Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity. doi.org/10.1038/s441... rdcu.be/eQxPN
- ❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more. www.nature.com/natcardiovas...
- Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis. doi.org/10.1038/s441... rdcu.be/ePzs6
- Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects. doi.org/10.1038/s441... rdcu.be/ePoLS
- Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques. doi.org/10.1038/s441... rdcu.be/eOBP0
- Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy. doi.org/10.1038/s441... rdcu.be/eOoxB
- Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target. doi.org/10.1038/s441... rdcu.be/eOeTA
- Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach. doi.org/10.1038/s441... rdcu.be/eNFJV
- Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets. doi.org/10.1038/s441... rdcu.be/eL2nN
- ❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.
- Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease. doi.org/10.1038/s441... rdcu.be/eKY2S
- Research | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts. doi.org/10.1038/s441... rdcu.be/eKNZT
- Research | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium. doi.org/10.1038/s441... rdcu.be/eKnDf
- Research | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function. doi.org/10.1038/s441... rdcu.be/eKcfF
- Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish. doi.org/10.1038/s441... rdcu.be/eJ3sB
- Research | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes. @DelbridgeLab doi.org/10.1038/s441... rdcu.be/eJSl7
- ❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more! www.nature.com/natcardiovas...
- Our chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work
- Research | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy. doi.org/10.1038/s441...
- ❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more! www.nature.com/natcardiovas...
- Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation. rdcu.be/eArYg doi.org/10.1038/s441...
- Ding, Y., Chen, J., Liu, S. et al show that tetraspanin regulates the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport to balance Cdc42 and RhoA activities and influence vascular inflammation. rdcu.be/eym4W
- Research | Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts. rdcu.be/exm9t
- Research| Chou et al. demonstrate that activation of the thrombin receptor PAR1 in the lung lymphatic vasculature augments lung lymphatic drainage in models of lung injury. rdcu.be/ewDHm
- ❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! www.nature.com/natcardiovas...
- Research | Yang et al draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of cardiovascular disease. doi.org/10.1038/s441...
- Research | Jafari and colleagues reveal disease severity–linked right ventricle remodelling in pulmonary hypertension and identify key molecules, unveiling mechanisms of right ventricle recovery after pulmonary endarterectomy. rdcu.be/evlHO
- Research | Li, Lu et al. Demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRE-dependent H3.3 deposition mechanism and facilitates vascular regeneration. rdcu.be/evbUz
- Research | Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy. rdcu.be/euGtI
- Research | Pocock et al. reveal that transient activation of 5’ AMP-activated protein kinase and oestrogen-related receptor drives robust maturation of human cardiac organoids, enabling the modelling of desmoplakin cardiomyopathy. @qimrb.bsky.social rdcu.be/et6S0
- Research | Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a marker for embryonic coronary artery endothelial cells and a regulator of coronary vascular remodelling and morphogenesis. rdcu.be/etLrc
- Research| Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and resulting cardiomyocyte death and cardiac dysfunction. rdcu.be/etxLM
- ❤️Our June issue is out❤️Read about the insight from the LILACS trial on T-cell regulation in cardiology, empagliflozin’s role in protecting the kidney and preventing heart failure in the EMPACT-MI trial, and more! www.nature.com/natcardiovas...
- Research| Wang, Tang et al. develop an iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near the CCDC141, IGF1R, TTN, and TNKS loci. doi.org/10.1038/s441... rdcu.be/epB59
- Research| Case et al. report that low-dose interleukin-2 clonally expands Tregs and maintains their suppressive program by bypassing BACH2 downregulation in patients with acute coronary syndrome from the LILACS trial. @aydencase.bsky.social rdcu.be/ephaW
- Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions. rdcu.be/en0hU
- Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. rdcu.be/enbAz
- Research| Qian, Ugurlu, Fairweather, et al. generate more than 3800 #CardiacDigitalTwins from imaging and ECGs to reveal electrophysiological insights and their links to cardiac function, lifestyle, mental health and clinical outcomes. rdcu.be/em0NT
- ❤️Our May issue is out❤️Read our three articles focused on atherosclerosis, describing TLO-like structures within plaques, FDX1’s protective role, and how gut microbiota-derived bile acids suppress platelet activation, and more! www.nature.com/natcardiovas...
- Research| Adamopoulos, Rovas et al. show that high regional wall shear stress correlates with fibrosis and electrical scarring in the left atrium of patients with atrial fibrillation, providing insight into the development of fibrotic tissue. rdcu.be/emh6y
- Research | Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. rdcu.be/el1Xr
- Research | Ling, Liu, and colleagues introduce MSR, a multiscale recursive algorithm that enhances cardiac microscopy for precise cardiovascular signal extraction, and validate the approach in vitro and in vivo. rdcu.be/elnFv
- Review | Fankhauser et al. provide an in-depth review of preclinical mouse models used to study immune checkpoint inhibitor-associated myocarditis and discuss potential improvements to the field to strengthen our understanding. rdcu.be/ek2Dh
- Research | Fan, Zheng, Zhan, Xu, Liu et al. reveal that the RNA-binding protein ARID5A drives inflammaging through the NF-kB-TBK1 pathway, and inactivating myocardial ARID5A attenuates cardiac senescence and functional decline. rdcu.be/ej7ww
- Research| Li et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures within the plaques and their potential functions and implications. rdcu.be/ejPd5
