Alexandra Teslenko
Postdoctoral Researcher👩🔬@CeTPD, Alessio Ciulli Lab, Dundee 🇬🇧
Biophysical Chemistry | Chemical and Structural Biology | Drug Discovery
- Reposted by Alexandra TeslenkoExcited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
- Reposted by Alexandra TeslenkoIn today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11
- Reposted by Alexandra TeslenkoExcited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/... It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
- Reposted by Alexandra Teslenko1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? www.biorxiv.org/content/10.1... #TranscriptionFactors #IDPs #SingleMolecule #Biophysics
- Reposted by Alexandra TeslenkoOur new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...
- If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬 Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support! doi.org/10.1126/scia...
- Using single-molecule dynamics, we observe real-time vPRC1 ubiquitylation of the chromatin fibers. vPRC1 dynamically engages chromatin, a process depending on E2 and H2Aub, while its PCGF subunit governs the formation of the catalytically competent complex with E2~Ub and enzymatic processivity.
- We are very grateful for the long-time financial support from the @erc.europa.eu, @snsf.ch, and EPFL (EDCH) who made this work possible! 🍀
