Henry McSorley
I use parasites to mess with the immune system. Reader at University of Dundee. I also like bikes and cats.
- Reposted by Henry McSorleyDelighted to see our new review online. It was an absolute pleasure to be invited to write this for @scienceimmuno.bsky.social with @judiallen.bsky.social & @james-ep.bsky.social - we hope you enjoy our overview of serous cavity #immunology ☀️ www.science.org/doi/10.1126/...
- Reposted by Henry McSorleyImpact tracking platform Researchfish will be closed down next year, its owners Elsevier have confirmed. Tom Williams reports #academicsky #impact timeshighereducation.com/news/impact-trackin…
- I realise its not the main thing here, but Denmark does not decide the Nobel Peace prize... Its based in Norway? Which is a different country? Also, obviously, insane.
- Reposted by Henry McSorleymad king moment from the PBS Newshour correspondent
- Reposted by Henry McSorleyCheck out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
- I presume once you've reviewed and edited sufficient numbers of manuscripts, you max out your XP, level up, then start getting paid for it. Right?
- Reposted by Henry McSorley[This post could not be retrieved]
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- Reposted by Henry McSorley"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
- Reposted by Henry McSorley'Type 2 immunity in health and disease' takes place 11am–12:45pm, Wed 3 Dec! Explore the cells and signals driving type 2 responses and why their regulation remains elusive by joining this parallel session at #BSI25. Registration is still open: bit.ly/3IkxWq8
- Reposted by Henry McSorleyGood morning to Brazilian reporter Manuela Borges, who’s been waiting eleven years for this petty moment. ❤️ 🇧🇷
- Reposted by Henry McSorleytype for books used to be set using little metal letters built into words in racks and then inked and pressed on to paper. If you had stock phrases you wanted to reuse a lot you could make a cast of them called a ‘stereotype’. The sound of them *clicking* into place, in French, is ‘cliché’
- Reposted by Henry McSorley📣 Registration is open for #SIGNET26! Join immunologists from across Scotland on 11 March 2026 for a full day of research talks, networking & collaboration. Featuring keynotes from Prof Graham Anderson & Prof Tracy Hussell! Sign up today 👉 bit.ly/49VL6FA
- Reposted by Henry McSorley
- Reposted by Henry McSorleyyou know how people always say "oh haha I put off doing this admin task for ages and ages and turns out it was fine and took no time" well I put off doing *this* admin task for weeks and actually it fucking sucks and it's taking soooo long, it's hateful, so there
- Reposted by Henry McSorley[This post could not be retrieved]
- Reposted by Henry McSorleyMy PhD work is (finally) published in Science Signaling! And it made the cover! Here’s what we found 🧵⬇️ www.science.org/doi/10.1126/...
- Reposted by Henry McSorleyHappy Longest Day Of The Year
- Reposted by Henry McSorleyIncredibly proud to share that our work on Cryptosporidium Oocyst Wall Proteins is published in @PLOSPathogens journals.plos.org/plospathogen... Led by previous PhD student @BacchettiRoss and carried on by current PhD student, Sarah Stevens.
- Reposted by Henry McSorleyurgently need you guys to know that this French politician below 1) didn't know he'd been appointed as a minister until he saw it on TV 2) reacted by going: "bah pfff voilà"
- Reposted by Henry McSorleyDr. Seuss went hard during WWII. Lessons should have been learned.
- Reposted by Henry McSorleyIf eating scotch eggs in an Austin Allegro had a face.
- Reposted by Henry McSorley
- Reposted by Henry McSorleyYay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...
- real bravery
- The South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy. www.chosun.com/english/nati...
- Doing the Glentress 7 today - 7h mountain bike race. I plan to become a machine which turns peanut butter and jam sandwiches into laps.
- My usual performance goes: Lap 1: take it slow, pace yourself. Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next… Lap 3: imma do a hot lap! Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no. Lap 5: screaming, crying, throwing up
- Currently done lap 3 and has gone exactly as above, with a major crash due to overexcitement. (Bike and rider are fine) I plan to learn nothing from this.
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View full threadDone! 7 laps, 67 km. To be clear, the race is still going on, IM done. 3000 calories - could eat… strava.app.link/8fs8DA6u0Wb
- Reposted by Henry McSorleyWe're looking for a Lead Scientist to join Flow Cytometry Centre in Aberdeen! Fantastic opportunity to deliver services, work with varied research groups, promote cytometry and further develop the facility. Aberdeen is a great place to live/work- APPLY NOW www.abdnjobs.co.uk/vacancy/cyto...
- Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
- This story started when we realised that all of the immunomodulators we had identified from Hpb (HpARI, HpBARI and TGM) were related in their domain structure - all consist of strings of CCP domains. Turns out the CCP domain family is massively (and uniquely) expanded in the Hpb genome.
- We screened the CCP domain protein family to see if there were other host immune factor binders, using an AVEXIS protein-protein interaction screen. The screen confirmed that HpBARI binds ST2, and that TGM1 binds TGFBR2 (reassuring) and identified one new hit - a protein which bound RELM-beta.
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View full threadThats where the story ends at the moment - we would love to look at the in vivo effects of HpBoRB against RELM-beta (does it suppress RELM-beta's activity?) but we ran out of time in Viv's PhD. If anyone has any interesting RELM-beta assays they would like to try HpBoRB in, hit us up!
- Reposted by Henry McSorleyExtremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...
- Reposted by Henry McSorleyAllergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉 @hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social @profjudiallen.bsky.social
- Reposted by Henry McSorleyIn a moment like this, when tensions are high, part of the job of the president is to remind us of the ties that bind us together.
- Reposted by Henry McSorleyJapan has a wrestling camp for kids where at the end they have a show match in front of their parents to show off what they learned. Thought you'd enjoy this.
- Reposted by Henry McSorleyHominid re-diversification
- Reposted by Henry McSorleyPangolin taking a mud bath: #AGoodPlace Source: www.reddit.com/r/NatureIsFu...
- Reposted by Henry McSorleySave the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟
- I have marked 6 MSc theses in 2 days and I cant read any more words. No more words thank you. Or acronyms. Especially acronyms.
- Great postdoc opportunity available in the Konkel lab in Manchester!
- New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below: www.jobs.manchester.ac.uk/Job/JobDetai... www.bmh.manchester.ac.uk/research/ins...
- Reposted by Henry McSorleyIL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity Cell www.cell.com/cell/fulltex...
- Reposted by Henry McSorley"chatGPT 5 is like having a bunch of phds in your pocket" here's ten trillion dollars "bluesky is having an *actual* bunch of phds in your pocket" dying platform. it disgusts me
- Reposted by Henry McSorleySuper proud that my PhD paper is finally out! doi.org/10.1111/all.... RSV leaves long-lasting marks on the lung, potentially boosting future immune responses but also contributing to allergen sensitisation.
- Reposted by Henry McSorleyWe made a short animation explaining what goes wrong in the lungs during asthma! 🫁🎬 Designed for the public, students & patients—check out how immune cells respond to threats & how asthma treatments work. Big thanks to @WellcomeTrust & Acteria!
- Gonna steal this sign for my office door
- Reposted by Henry McSorleyKarolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...
- Reposted by Henry McSorleyBaby voice: Things can be good without being perfect. You must learn to grasp this fact. If you are unable to do so, you will have a very thankless life, politically and personally.
- Reposted by Henry McSorleyIn our latest work we've explored associations between the fecal bile acid pool and helminth infection status in school aged children in Uganda. Have a read and see what we found!
- Delighted to share my latest publication as a PhD candidate in @drlarey.bsky.social’s lab at @uvicscience.bsky.social! With our international collaborators we’re excited to share our findings on the associations between #helminths and fecal bile acids! 🪱 doi.org/10.1038/s415...
- Reposted by Henry McSorleyGreat to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...
- Reposted by Henry McSorleyThe fantastic Menon Lab (@madhvimenon.bsky.social) in the @lydiabeckeriii.bsky.social in Manchester are hiring!! 🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨 www.jobs.manchester.ac.uk/Job/JobDetai... Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky
- The perils of living in cow-country. I thought I was putting the grass cuttings on the compost heap. Apparently no, I was filling up the cow feeding trough. The cows made it clear that this was the best day ever.
- Reposted by Henry McSorley[This post could not be retrieved]
- Reposted by Henry McSorley🚨 Abstract submissions are OPEN for the British Society for Immunology Congress 2025! #BSI25 Join 1,500+ immunologists in Liverpool between 1–4 Dec, for 4 days of science, workshops & networking. Submit your abstract by 3 Sept & showcase your research! 🔗 bit.ly/4kYXvLN
- Reposted by Henry McSorleyDelighted to be on the new Editorial Board and looking forward to helping refresh the BSI’s BiteSized Immunology resource ⬇️
- Reposted by Henry McSorleyWhat? I... WHAT??
- There are few things you less want to dig up in the garden than yellow tape saying “danger high voltage”. I’m not saying it’s the worst thing, but it’s top 5.
- Reposted by Henry McSorleybritish fan chat
- Reposted by Henry McSorleyOur latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!
- Reposted by Henry McSorleymRNAs encoding adjuvant proteins boost immunity. A fantastic study from Hunter et al shows the value of IL12. Study validates original work on this concept, ref below. Kudos to the authors on this exciting discovery! www.science.org/doi/10.1126/...
- 🚨 New McSorley lab paper just out in Cell Reports! Very happy to see this published - it has been a lot of work, and its turned into a really nice story. In it, we show that HpARI+HpBARI can be used as vaccines Tutorial thread below (1/16): www.sciencedirect.com/science/arti...
- We first begun by looking at the effects of HpARI and HpBARI during H. polygyrus bakeri (Hpb) infection. You can see HpBARI working as it makes the IL-33 receptor, ST2, disappear on flow cytometry staining. We found that this effect is seen systemically, but only during the first week of infection.
- This, combined with some asthma data, implied that the first week of Hpb infection (when the worm is in the wall of the gut) is when the immunomodulatory action happens.
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View full thread@drdsmyth.bsky.social now on here!
- Stayed last weekend in the wonderful Bamff wildland. So many beavers! Right outside the window! Morning coffee and beavers = excellent.
- Got some helpers for today’s marking. Baby cows are best cows.
- Reposted by Henry McSorleyFriday’s @thetimes.com cartoon times.newsprints.co.uk/morten-morla...
- Reposted by Henry McSorley🧪 New online today! Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived #macrophages during #influenza A infection www.mucosalimmunology.org/article/S193...
- I get an absurd amount of joy watching the happy spring trees get their happy Spring leaves on. Absurd.
- Reposted by Henry McSorleyMy latest @newscientist.com cartoon
