Mattia Frontini
Functional Genomics, Rare Diseases and Cardiovascular Disease @ Exeter University
ORCID 0000-0001-8074-6299
- Reposted by Mattia FrontiniWe've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...
- Reposted by Mattia Frontini🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!
- Reposted by Mattia Frontini🚨 Applications open! 🚨 Medical students: Apply for our 8-week Summer Scholarship in medical mycology. Gain lab experience, study design & data analysis skills, no prior expertise needed! 📍 Exeter or partner institutions 📅 Deadline: 28 Feb 2026 👉 buff.ly/PrpeVN4
- Reposted by Mattia Frontini🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Mattia FrontiniYou wish to do a #Postdoc supported by a unique network? My Lab will host PULSE #Postdoc Applicants Program by the prestigious @scilifelab.se Check this out and get in touch with me if you are interested in top-notch #Genomics, #DevBio and #Cancer Biology 👇 www.scilifelab.se/research/pul...
- Reposted by Mattia Frontini🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD! tinyurl.com/29uuc5by
- Reposted by Mattia FrontiniOur new study defines a distinct #neurogenetic condition arising from recurrent structural variants at 16p13.3 palindrome. Individuals show progressive ataxia, cognitive decline, and a characteristic MRI pattern with caudate & cerebellar atrophy. #Genomics #RareDisease 🧵1/3
- Reposted by Mattia FrontiniIn ~5 hours…
- 🔔This Wednesday , in #FragileNucleosome seminar, we are excited to host @ishtiaqueh.bsky.social of Pastor lab and Prof. Sarah Teichmann, @teichlab.bsky.social, to tell us about their exciting studies! 🗓️Register here for upcoming session and the entire series: us06web.zoom.us/webinar/regi...
- Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases. www.biorxiv.org/content/10.1... @nicolesoranzo.bsky.social @npirastu.bsky.social
- Reposted by Mattia FrontiniCongratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology www.science.org/doi/10.1126/...
- Reposted by Mattia FrontiniPlease repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...
- Reposted by Mattia Frontiniboth are right: the best is marine microbiology
- Reposted by Mattia FrontiniReminder! Deadline to apply is midday today!
- Reposted by Mattia FrontiniEver wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...
- Reposted by Mattia FrontiniWhat is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...
- Reposted by Mattia Frontini🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...
- Reposted by Mattia FrontiniA quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.
- Reposted by Mattia Frontini🗣️ "You can get test kits sent to you - it's discreet and quick and easy." Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊 FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit #ECFC #SemperFidelis
- Reposted by Mattia FrontiniVery much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome" 📅 02 October 2025 (today!) ⏰ 4 pm GMT Join: us02web.zoom.us/webinar/regi...
- Reposted by Mattia FrontiniAs we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive. I hope you like it! www.biorxiv.org/content/10.1...
- Reposted by Mattia FrontiniNext up! Two applications of MAVE! 🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants. 🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
- Reposted by Mattia FrontiniActivity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Reposted by Mattia FrontiniHeads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned
- Reposted by Mattia FrontiniAre you interested in applying for a studentship with us? Come along to our first online Candidate Support Webinar for tips on preparing your application. Thursday 11th September at 4pm (UK time). Click here to register: events.teams.microsoft.com/event/83d5eb...
- Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)
- Reposted by Mattia FrontiniWe're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...
- Reposted by Mattia FrontiniNew work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries www.sciencedirect.com/science/arti...
- Reposted by Mattia FrontiniA big blow to All of Science, not just Harvard, not just the Fly community, not just Genetics. All of Science. Turbocharge was just switched off. Flies gave us so many insights.
- Reposted by Mattia FrontiniExcited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...
- Reposted by Mattia FrontiniMy team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
- Reposted by Mattia FrontiniPer chi volesse, presenterò il mio libro a Palmi (RC) il prossimo 2 agosto.
- Reposted by Mattia FrontiniThe Perturbation Catalogue is here! A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place. The beta version is now live. Find out more and try the platform: www.ebi.ac.uk/about/news/u... 🧬🖥️
- Reposted by Mattia FrontiniInterested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
- Reposted by Mattia FrontiniA 6-year long study from the Lab is finally out @genomeresearch.bsky.social Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social Why is our work Important? Discover it in the quick Bluetorial 👇 genome.cshlp.org/content/earl...
- Reposted by Mattia Frontini🚨Our user survey is closing on 24 July. Only a few days left to share your views. Please take 10 minutes to help us demonstrate the value of the data resources we manage with our collaborators. Complete survey 👇 www.surveymonkey.com/r/QGFMBH8?ch... 🖥️🧬 #FAIRdata
- Reposted by Mattia FrontiniTw-Eat Sweet Currently available FREE as an eBook - anyone can read it with the free Kindle App. www.amazon.co.uk/dp/B094J9ZS8X #cookbooks #CookSky #FoodSky #BookSky #KindleDeal #BookGiveaway #FreeBook #Kindle #eBook #Foodie #SimpleRecipes
- Reposted by Mattia FrontiniRegistration for Transcription and Chromatin UK is OPEN! Taking place from September 17 to 19, 2025, this conference will showcase cutting-edge research and is a ‘must-attend’ event for the UK transcription and chromatin community & both at home and abroad. Pl register ow.ly/7QQb50W9Alo & share
- Reposted by Mattia Frontini"People don't do actual training in how to do animal experiments and there's such a lot that you need to think about that you just wouldn't realise unless somebody tells you." Apply by 31st August. Find out more about our Mouse Models for Human Disease Workshop: www.har.mrc.ac.uk/training/cou...
- Reposted by Mattia FrontiniThanks for the reminder @janemunday.bsky.social. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on. slate.com/technology/2...
- Reposted by Mattia FrontiniTextbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22
- Reposted by Mattia FrontiniStarting in an hour!
- Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series! In case you haven't joined any of the previous 2025 sessions, here is registration link: us06web.zoom.us/webinar/regi...
- Reposted by Mattia FrontiniIf you are in London a week today and are free early evening, please come along to my talk at @royalsociety.org (free!). If you can’t make it, it will be live-streamed and subsequently available online…
- Reposted by Mattia FrontiniDelighted that the 'flagship' manuscript on our @genesandhealth.bsky.social 44k exomes (British Pakistanis & Bangladeshis) is now preprinted. Great academic-industry collaboration. Lots of new associations (mostly additive, a few recessive) and new insights into homoz knockouts & drug discovery.
- Preprint alert! 🚨 doi.org/10.1101/2025... Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social! We present several great results, and I’m thrilled to highlight the pieces I worked on:
- Reposted by Mattia Frontini"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!
- Reposted by Mattia FrontiniCan you give blood?
- Reposted by Mattia FrontiniCarer's Awards, funded by the Genetics Society, are available to support 3 participants of the First UK Zebrafish Meeting with caring responsibilities. @gensocuk.bsky.social More info at exeter.ac.uk/ukzfmeeting
- Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! 🐠 Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...
- Reposted by Mattia FrontiniLooking for a thesis internship? Join the Soranzo Group at @humantechnopole.bsky.social ! 🔬 Dive into cutting-edge science, develop new skills, and be part of a dynamic team. Apply now ➡️ careers.humantechnopole.it/o/curricular... #internship #research #genomics #bioinformatics #thesisopportunity
- Reposted by Mattia FrontiniInterested in training for the role of a scientific journal peer reviewer? Curious how you can fine-tune your manuscript to shine its brightest for reviewers?. Mark your #EHA2025 agenda - HemaSphere has you covered! 🎓Peer Review Workshop 📆Friday, June 13 ⏱️13:30 - 15:00 📍Milan MiCo, Room Ocean 2
- Reposted by Mattia FrontiniSee our new paper in @ajhgnews.bsky.social : Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists Explores blocks to implementing MAVE data into clinical variant interpretation @varianteffect.bsky.social authors.elsevier.com/a/1lDFkgeXDyy6
- While this is true, it also highlights that editors do not rely on their own judgment and, most likely, keep on using the same reviewers that are less than constructive. For how long can this model continue?
- The problem of unreasonable demands for more experiments came up at @fly-jedi.bsky.social (and many recent meetings). And remember the editors response: we ask for these because _you_ demand them as referees…
- Reposted by Mattia FrontiniURGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
- My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate. www.philanthropy.cam.ac.uk/give-to-camb...
- Reposted by Mattia FrontiniPlease repost: We have a postdoc position in Antifungal Immunity Research available to study T cell responses and fungal sensitization in atopic dermatitis. @lableibundgut.bsky.social @neil-gow.bsky.social @mrccmm.bsky.social For more details, visit: jobs.exeter.ac.uk/hrpr_webrecr...
- Reposted by Mattia FrontiniHow to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...
