The Dark Matter Project
Studying The Dark Matter of the Genome - everything noncoding 🧬
A collaborative scientific project at NYU Langone.
Account managed by Ran Brosh.
- Mammalian genome writing: Unlocking new length scales for genome engineering www.sciencedirect.com/science/arti...
- Reposted by The Dark Matter ProjectHappy to share that our review on mammalian genome writing with Jack Atwater, Ran Brosh, Jef Boeke, @jshendure.bsky.social and Matt Maurano is now out in @cellpress.bsky.social! www.sciencedirect.com/science/arti...
- 🧬Sign up to our free online 2026 Genome Writing Workshop 🧬 www.thedarkmatterproject.org/2026-genome-...
- www.biorxiv.org/content/10.6... Congrats to Dr. Noor Chalhoub who managed to defend her thesis and publish this paper on the same day!
- Enhancer cooperativity in the folded genome www.sciencedirect.com/science/arti...
- Structure and evolution-guided design of minimal RNA-guided nucleases www.biorxiv.org/content/10.6...
- High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/abs/10.1...
- How could one engineer a mouse carrying a LETHAL allele? A thread 🧵
- The answer is quite simple of course: make it conditional. But what if the lethality is induced by a 2.7 kb retrotransposon insertion into an X-linked gene? How would you CONDITIONALLY introduce this element?
- This is the problem we had to tackle when we engineered the first mouse model of X-linked Dystonia Parkinsonism, a disease caused by an SVA (SINE-VNTR-Alu) retrotransposon insertion in the essential TAF1 gene.
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View full threadDid it work? Hell yeah! Read our two companion preprints to learn more: bsky.app/profile/dark...
- We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism! biorxiv.org/content/10.1... AND biorxiv.org/content/10.1... @nyulangone.bsky.social
- One step closer to an LLM that understands novel DNA🧬 𝗜𝘁𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗱𝗲𝗲𝗽 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗺𝗼𝗱𝗲𝗹𝘀 𝘂𝘀𝗶𝗻𝗴 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗴𝗲𝗻𝗼𝗺𝗶𝗰𝘀. pubmed.ncbi.nlm.nih.gov/41125441 Congrats Andre Ribeiro-Dos-Santos and Matt Maurano!
- Reposted by The Dark Matter ProjectI am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!
