jydutheil.bsky.social
Evolutionary biology. Population genomics. Bioinformatics and statistics. Pipes and hats.
- New study from the Lab! Jinyang Liang assesses the possibility of inferring ancestral alleles (aka allele polarization) without outgroup sequence, using the ancestral recombination graph (ARG) alone. Here are some of our findings. (1/5)
- Polarizing SNPs without outgroup biorxiv.org/content/10.1101/202…
- When the ARG is known, polarization can be achieved with great accuracy at some positions, depending on the shape of the underlying marginal genealogy. (2/5)
- With currently available ARG inference methods, the polarization accuracy is lower than when using the true ARG. The best results are obtained by applying a UPGMA tree reconstruction on PSMC pairwise TMRCAs! (3/5)
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View full threadWork by @jinyangliang.bsky.social , welcome on Bluesky Jinyang!
- The call for PhD positions at the Max Planck Institute for Evolutionary Biology is now open, including one in my group! www.evolbio.mpg.de/3017297/appl.... If you are interested in playing with ancestral recombination graphs, please reach out!
