Wei-Lin Qiu
Postdoctoral Researcher in Robin Andersson lab at University of Copenhagen
- Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks. biorxiv.org/cgi/content/... Read more below! 1/12
- scE2G tackles the challenge of building cell-type-specific maps of enhancer-gene regulation. If we can do this well, we can build enhancer maps across thousands of human cell types from emerging single-cell atlases to interpret genetic variants and understand gene regulation. 2/12
- Using a gold-standard CRISPR perturbation dataset, we trained two logistic regression models: scE2G (ATAC) and scE2G (Multiome), that use single-cell ATAC-seq or single-cell multiomic ATAC and RNA-seq data, respectively. 3/12
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View full threadMany thanks to our amazing team, especially co-first author @mayayayas.bsky.social, and supervisors @randersson.bsky.social, @jengreitz.bsky.social 12/12
